Correlation between tumor angiogenesis and metastasis in breast cancer.

J. S. Chu, W. J. Lee, T. C. Chang, K. J. Chang, H. C. Hsu

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


New vessel formation (angiogenesis) plays an important role in the metastasis of cancer cells. To investigate the correlation between tumor angiogenesis and metastatic potential in breast cancer, the microvessel counts of tumor specimens from 81 women with primary infiltrating ductal carcinomas were examined. Histologic parameters (nodal status, tumor size and tumor grade) and hormone receptor status were also analyzed. We found that axillary node metastasis correlated significantly with the microvessel counts per 200x field and with tumor size, but not with age, tumor grade or hormone receptor status. Tumors without axillary node involvement had a lower microvessel count, irrespective of age, tumor size, tumor grade or hormone receptor status. Logistic regression demonstrated that the microvessel count provided the most important estimate of the relative risk of metastasis. These results suggest that, in invasive breast carcinoma, angiogenesis is closely related to metastatic potential.

Original languageEnglish
Pages (from-to)373-378
Number of pages6
JournalJournal of the Formosan Medical Association = Taiwan yi zhi
Issue number7
Publication statusPublished - Jul 1995

ASJC Scopus subject areas

  • General Medicine


Dive into the research topics of 'Correlation between tumor angiogenesis and metastasis in breast cancer.'. Together they form a unique fingerprint.

Cite this