Correlation between Pyrazinamide Activity and pncA Mutations in Mycobacterium tuberculosis Isolates in Taiwan

Tsi Shu Huang; Susan Shin-Jung Lee; Hui Zin Tu; Wen Kuei Huang; Yao Shen Chen; Chung Kai Huang; Shue Ren Wann; Hsi Hsun Lin; Yung Ching Liu

doi:10.1128/AAC.47.11.3672-3673.2003

Correlation between Pyrazinamide Activity and pncA Mutations in Mycobacterium tuberculosis Isolates in Taiwan

Tsi Shu Huang, Susan Shin-Jung Lee, Hui Zin Tu, Wen Kuei Huang, Yao Shen Chen, Chung Kai Huang, Shue Ren Wann, Hsi Hsun Lin, Yung Ching Liu

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

A total of 76 clinical Mycobacterium tuberculosis isolates from Taiwan were tested for pyrazinamidase activity, pyrazinamide susceptibility, and pncA mutations. Frequency of resistance to PZA rose with increases in resistance to first-line drugs. Of 17 pyrazinamide-resistant strains, 7 (3 of which had not been previously described) possessed mutations in the pncA gene.

Original language	English
Pages (from-to)	3672-3673
Number of pages	2
Journal	Antimicrobial Agents and Chemotherapy
Volume	47
Issue number	11
DOIs	https://doi.org/10.1128/AAC.47.11.3672-3673.2003
Publication status	Published - Nov 2003
Externally published	Yes

ASJC Scopus subject areas

Pharmacology (medical)
Infectious Diseases
Pharmacology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/AAC.47.11.3672-3673.2003

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title = "Correlation between Pyrazinamide Activity and pncA Mutations in Mycobacterium tuberculosis Isolates in Taiwan",

abstract = "A total of 76 clinical Mycobacterium tuberculosis isolates from Taiwan were tested for pyrazinamidase activity, pyrazinamide susceptibility, and pncA mutations. Frequency of resistance to PZA rose with increases in resistance to first-line drugs. Of 17 pyrazinamide-resistant strains, 7 (3 of which had not been previously described) possessed mutations in the pncA gene.",

author = "Huang, {Tsi Shu} and {Shin-Jung Lee}, Susan and Tu, {Hui Zin} and Huang, {Wen Kuei} and Chen, {Yao Shen} and Huang, {Chung Kai} and Wann, {Shue Ren} and Lin, {Hsi Hsun} and Liu, {Yung Ching}",

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AU - Huang, Tsi Shu

AU - Shin-Jung Lee, Susan

AU - Tu, Hui Zin

AU - Huang, Wen Kuei

AU - Chen, Yao Shen

AU - Huang, Chung Kai

AU - Wann, Shue Ren

AU - Lin, Hsi Hsun

AU - Liu, Yung Ching

PY - 2003/11

Y1 - 2003/11

N2 - A total of 76 clinical Mycobacterium tuberculosis isolates from Taiwan were tested for pyrazinamidase activity, pyrazinamide susceptibility, and pncA mutations. Frequency of resistance to PZA rose with increases in resistance to first-line drugs. Of 17 pyrazinamide-resistant strains, 7 (3 of which had not been previously described) possessed mutations in the pncA gene.

AB - A total of 76 clinical Mycobacterium tuberculosis isolates from Taiwan were tested for pyrazinamidase activity, pyrazinamide susceptibility, and pncA mutations. Frequency of resistance to PZA rose with increases in resistance to first-line drugs. Of 17 pyrazinamide-resistant strains, 7 (3 of which had not been previously described) possessed mutations in the pncA gene.

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JF - Antimicrobial Agents and Chemotherapy

IS - 11

ER -

Correlation between Pyrazinamide Activity and pncA Mutations in Mycobacterium tuberculosis Isolates in Taiwan

Abstract

ASJC Scopus subject areas

UN SDGs

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