Correlation between joint [F-18] FDG PET uptake and synovial TNF-α concentration: A study with two rabbit models of acute inflammatory arthritis

Po Wei Lin; Ren Shyan Liu; Tsan Hon Liou; Li Chern Pan; Chi-Hsien Chen

doi:10.1016/j.apradiso.2007.06.006

Correlation between joint [F-18] FDG PET uptake and synovial TNF-α concentration: A study with two rabbit models of acute inflammatory arthritis

Po Wei Lin, Ren Shyan Liu, Tsan Hon Liou, Li Chern Pan, Chi-Hsien Chen

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

The objective of this study was to verify that the [F-18]FDG PET synovial uptake is correlated with the synovial fluid (SF) TNF-α concentration. Two rabbit models of acute inflammatory arthritis induced by human interleukin-8 and lipopolysaccharide were used. Modified standard uptake values (MSUVs) obtained from PET images of the animals were compared with results of SF TNF-α measurements. Statistically significant correlations were found between the MSUVs and the SF TNF-α ratios. An equation to estimate the TNF-α ratio from a MSUV was also derived.

Original language	English
Pages (from-to)	1221-1226
Number of pages	6
Journal	Applied Radiation and Isotopes
Volume	65
Issue number	11
DOIs	https://doi.org/10.1016/j.apradiso.2007.06.006
Publication status	Published - Nov 2007

Keywords

Arthritis severity
Inflammatory arthritis
Positron emission tomography
Tumor necrosis factor alpha
[F]-fluoro-2-deoxyglucose

ASJC Scopus subject areas

Radiation

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10.1016/j.apradiso.2007.06.006

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title = "Correlation between joint [F-18] FDG PET uptake and synovial TNF-α concentration: A study with two rabbit models of acute inflammatory arthritis",

abstract = "The objective of this study was to verify that the [F-18]FDG PET synovial uptake is correlated with the synovial fluid (SF) TNF-α concentration. Two rabbit models of acute inflammatory arthritis induced by human interleukin-8 and lipopolysaccharide were used. Modified standard uptake values (MSUVs) obtained from PET images of the animals were compared with results of SF TNF-α measurements. Statistically significant correlations were found between the MSUVs and the SF TNF-α ratios. An equation to estimate the TNF-α ratio from a MSUV was also derived.",

keywords = "Arthritis severity, Inflammatory arthritis, Positron emission tomography, Tumor necrosis factor alpha, [F]-fluoro-2-deoxyglucose",

author = "Lin, {Po Wei} and Liu, {Ren Shyan} and Liou, {Tsan Hon} and Pan, {Li Chern} and Chi-Hsien Chen",

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T1 - Correlation between joint [F-18] FDG PET uptake and synovial TNF-α concentration

T2 - A study with two rabbit models of acute inflammatory arthritis

AU - Lin, Po Wei

AU - Liu, Ren Shyan

AU - Liou, Tsan Hon

AU - Pan, Li Chern

AU - Chen, Chi-Hsien

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AB - The objective of this study was to verify that the [F-18]FDG PET synovial uptake is correlated with the synovial fluid (SF) TNF-α concentration. Two rabbit models of acute inflammatory arthritis induced by human interleukin-8 and lipopolysaccharide were used. Modified standard uptake values (MSUVs) obtained from PET images of the animals were compared with results of SF TNF-α measurements. Statistically significant correlations were found between the MSUVs and the SF TNF-α ratios. An equation to estimate the TNF-α ratio from a MSUV was also derived.

KW - Arthritis severity

KW - Inflammatory arthritis

KW - Positron emission tomography

KW - Tumor necrosis factor alpha

KW - [F]-fluoro-2-deoxyglucose

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Correlation between joint [F-18] FDG PET uptake and synovial TNF-α concentration: A study with two rabbit models of acute inflammatory arthritis

Abstract

Keywords

ASJC Scopus subject areas

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