Correction of malignant behavior of tumor cells by traditional Chinese herb medicine through a restoration of p53

Win Ping Deng; Ming Wei Chao; Wen-FuThomas Lai; Chi Sun; Chen Yen Chung; Cheng Chia Wu; I. Hsin Lin; Jeng Jong Hwang; Chih Hsiung Wu; Wen Ta Chiu; Chia Yu Chen; John Leslie Redpath

doi:10.1016/j.canlet.2005.03.031

Correction of malignant behavior of tumor cells by traditional Chinese herb medicine through a restoration of p53

Win Ping Deng, Ming Wei Chao, Wen-FuThomas Lai, Chi Sun, Chen Yen Chung, Cheng Chia Wu, I. Hsin Lin, Jeng Jong Hwang, Chih Hsiung Wu, Wen Ta Chiu, Chia Yu Chen, John Leslie Redpath

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

We have previously demonstrated that a UVC-induced tumorigenic HeLa x skin fibroblast cell line could be induced to form a more normal phenotypic state ('reversion'), including loss of IAP expression. We have now used the loss of IAP expression to monitor the enhancement of this reversion in the cervical cancer cell line, HeLa, by a traditional Chinese herb medicine (TCM), Yigan Kang (YGK). IAP level decreased, and the reversion frequency increased, in a dose-dependent manner at concentrations of YGK of more than 10 mg. YGK significantly repressed E6/E7 oncogenes at the transcriptional level, with subsequent reactivation of p53 and p21 expression (P

Original language	English
Pages (from-to)	315-327
Number of pages	13
Journal	Cancer Letters
Volume	233
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2005.03.031
Publication status	Published - Feb 28 2006

Keywords

Cancer reversion
HPV
IAP
TCM
Yigan Kang
p53

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.canlet.2005.03.031

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title = "Correction of malignant behavior of tumor cells by traditional Chinese herb medicine through a restoration of p53",

abstract = "We have previously demonstrated that a UVC-induced tumorigenic HeLa x skin fibroblast cell line could be induced to form a more normal phenotypic state ('reversion'), including loss of IAP expression. We have now used the loss of IAP expression to monitor the enhancement of this reversion in the cervical cancer cell line, HeLa, by a traditional Chinese herb medicine (TCM), Yigan Kang (YGK). IAP level decreased, and the reversion frequency increased, in a dose-dependent manner at concentrations of YGK of more than 10 mg. YGK significantly repressed E6/E7 oncogenes at the transcriptional level, with subsequent reactivation of p53 and p21 expression (P",

keywords = "Cancer reversion, HPV, IAP, TCM, Yigan Kang, p53",

author = "Deng, {Win Ping} and Chao, {Ming Wei} and Wen-FuThomas Lai and Chi Sun and Chung, {Chen Yen} and Wu, {Cheng Chia} and Lin, {I. Hsin} and Hwang, {Jeng Jong} and Wu, {Chih Hsiung} and Chiu, {Wen Ta} and Chen, {Chia Yu} and Redpath, {John Leslie}",

note = "Funding Information: This study was supported by grant from the Committee on Chinese Medicine and Pharmacy, Department of Health, Taiwan, ROC (CCMP94-RD-023), and the Department of Chinese Medicine, Chung Gung Memorial Hospital, Chung-Gung University.",

year = "2006",

month = feb,

day = "28",

doi = "10.1016/j.canlet.2005.03.031",

language = "English",

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T1 - Correction of malignant behavior of tumor cells by traditional Chinese herb medicine through a restoration of p53

AU - Deng, Win Ping

AU - Chao, Ming Wei

AU - Lai, Wen-FuThomas

AU - Sun, Chi

AU - Chung, Chen Yen

AU - Wu, Cheng Chia

AU - Lin, I. Hsin

AU - Hwang, Jeng Jong

AU - Wu, Chih Hsiung

AU - Chiu, Wen Ta

AU - Chen, Chia Yu

AU - Redpath, John Leslie

N1 - Funding Information: This study was supported by grant from the Committee on Chinese Medicine and Pharmacy, Department of Health, Taiwan, ROC (CCMP94-RD-023), and the Department of Chinese Medicine, Chung Gung Memorial Hospital, Chung-Gung University.

PY - 2006/2/28

Y1 - 2006/2/28

N2 - We have previously demonstrated that a UVC-induced tumorigenic HeLa x skin fibroblast cell line could be induced to form a more normal phenotypic state ('reversion'), including loss of IAP expression. We have now used the loss of IAP expression to monitor the enhancement of this reversion in the cervical cancer cell line, HeLa, by a traditional Chinese herb medicine (TCM), Yigan Kang (YGK). IAP level decreased, and the reversion frequency increased, in a dose-dependent manner at concentrations of YGK of more than 10 mg. YGK significantly repressed E6/E7 oncogenes at the transcriptional level, with subsequent reactivation of p53 and p21 expression (P

AB - We have previously demonstrated that a UVC-induced tumorigenic HeLa x skin fibroblast cell line could be induced to form a more normal phenotypic state ('reversion'), including loss of IAP expression. We have now used the loss of IAP expression to monitor the enhancement of this reversion in the cervical cancer cell line, HeLa, by a traditional Chinese herb medicine (TCM), Yigan Kang (YGK). IAP level decreased, and the reversion frequency increased, in a dose-dependent manner at concentrations of YGK of more than 10 mg. YGK significantly repressed E6/E7 oncogenes at the transcriptional level, with subsequent reactivation of p53 and p21 expression (P

KW - Cancer reversion

KW - HPV

KW - IAP

KW - TCM

KW - Yigan Kang

KW - p53

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JO - Cancer Letters

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ER -

Correction of malignant behavior of tumor cells by traditional Chinese herb medicine through a restoration of p53

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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