Corpus callosotomy in a patient of hemimegalencephaly and Lennox-Gastaut syndrome

Shang Yeong Kwan; Hann Yeh Shyu; Ji Ho Lin; Tai Tong Wong; Kai Ping Chang; Chun Hing Yiu

doi:10.1016/j.braindev.2008.03.003

Corpus callosotomy in a patient of hemimegalencephaly and Lennox-Gastaut syndrome

Shang Yeong Kwan
, Hann Yeh Shyu
, Ji Ho Lin
, Tai Tong Wong
, Kai Ping Chang
, Chun Hing Yiu

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

We report the case of a girl with hemimegalencephaly (HME) and Lennox-Gastaut syndrome (LGS) treated by callosotomy at 1 year of age. Over 10 years, her seizure frequency and severity decreased markedly. Hemispherectomy is the main surgical option for HME although HME appears to correlate with a less favorable seizure outcome. However, the clinical presentation of LGS and possible generalized cortical dysplasia, which is indicative of a secondarily generalized epilepsy, might predict a favorable surgical outcome of corpus callosotomy in patients of HME, as in our case.

Original language	English
Pages (from-to)	643-646
Number of pages	4
Journal	Brain and Development
Volume	30
Issue number	10
DOIs	https://doi.org/10.1016/j.braindev.2008.03.003
Publication status	Published - Nov 2008
Externally published	Yes

Keywords

Corpus callosotomy
Epilepsy
Generalized cortical dysplasia
Hemimegalencephaly
Lennox-Gastaut syndrome

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Developmental Neuroscience
Clinical Neurology

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10.1016/j.braindev.2008.03.003

Cite this

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title = "Corpus callosotomy in a patient of hemimegalencephaly and Lennox-Gastaut syndrome",

abstract = "We report the case of a girl with hemimegalencephaly (HME) and Lennox-Gastaut syndrome (LGS) treated by callosotomy at 1 year of age. Over 10 years, her seizure frequency and severity decreased markedly. Hemispherectomy is the main surgical option for HME although HME appears to correlate with a less favorable seizure outcome. However, the clinical presentation of LGS and possible generalized cortical dysplasia, which is indicative of a secondarily generalized epilepsy, might predict a favorable surgical outcome of corpus callosotomy in patients of HME, as in our case.",

keywords = "Corpus callosotomy, Epilepsy, Generalized cortical dysplasia, Hemimegalencephaly, Lennox-Gastaut syndrome",

author = "Kwan, \{Shang Yeong\} and Shyu, \{Hann Yeh\} and Lin, \{Ji Ho\} and Wong, \{Tai Tong\} and Chang, \{Kai Ping\} and Yiu, \{Chun Hing\}",

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doi = "10.1016/j.braindev.2008.03.003",

language = "English",

volume = "30",

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T1 - Corpus callosotomy in a patient of hemimegalencephaly and Lennox-Gastaut syndrome

AU - Kwan, Shang Yeong

AU - Shyu, Hann Yeh

AU - Lin, Ji Ho

AU - Wong, Tai Tong

AU - Chang, Kai Ping

AU - Yiu, Chun Hing

PY - 2008/11

Y1 - 2008/11

N2 - We report the case of a girl with hemimegalencephaly (HME) and Lennox-Gastaut syndrome (LGS) treated by callosotomy at 1 year of age. Over 10 years, her seizure frequency and severity decreased markedly. Hemispherectomy is the main surgical option for HME although HME appears to correlate with a less favorable seizure outcome. However, the clinical presentation of LGS and possible generalized cortical dysplasia, which is indicative of a secondarily generalized epilepsy, might predict a favorable surgical outcome of corpus callosotomy in patients of HME, as in our case.

AB - We report the case of a girl with hemimegalencephaly (HME) and Lennox-Gastaut syndrome (LGS) treated by callosotomy at 1 year of age. Over 10 years, her seizure frequency and severity decreased markedly. Hemispherectomy is the main surgical option for HME although HME appears to correlate with a less favorable seizure outcome. However, the clinical presentation of LGS and possible generalized cortical dysplasia, which is indicative of a secondarily generalized epilepsy, might predict a favorable surgical outcome of corpus callosotomy in patients of HME, as in our case.

KW - Corpus callosotomy

KW - Epilepsy

KW - Generalized cortical dysplasia

KW - Hemimegalencephaly

KW - Lennox-Gastaut syndrome

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DO - 10.1016/j.braindev.2008.03.003

M3 - Article

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AN - SCOPUS:53349102711

SN - 0387-7604

VL - 30

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EP - 646

JO - Brain and Development

JF - Brain and Development

IS - 10

ER -

Corpus callosotomy in a patient of hemimegalencephaly and Lennox-Gastaut syndrome

Abstract

Keywords

ASJC Scopus subject areas

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