Coronary artery spasm: Review and update

Ming Jui Hung, Patrick Hu, Ming Yow Hung

Research output: Contribution to journalArticlepeer-review

117 Citations (Scopus)


Coronary artery spasm (CAS), an intense vasoconstriction of coronary arteries that causes total or subtotal vessel occlusion, plays an important role in myocardial ischemic syndromes including stable and unstable angina, acute myocardial infarction, and sudden cardiac death. Coronary angiography and provocative testing usually is required to establish a definitive diagnosis. While the mechanisms underlying the development of CAS are still poorly understood, CAS appears to be a multifactorial disease but is not associated with the traditional risk factors for coronary artery disease. The diagnosis of CAS has important therapeutic implications, as calcium antagonists, not β-blockers, are the cornerstone of medical treatment. The prognosis is generally considered benign; however, recurrent episodes of angina are frequently observed. We provide a review of the literature and summarize the current state of knowledge regarding the pathogenesis of CAS.

Original languageEnglish
Pages (from-to)1161-1171
Number of pages11
JournalInternational Journal of Medical Sciences
Issue number11
Publication statusPublished - Aug 28 2014


  • Coronary artery spasm
  • Prinzmetal's angina
  • Provocative testing

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Coronary artery spasm: Review and update'. Together they form a unique fingerprint.

Cite this