Core-shell structure microcapsules with dual pH-responsive drug release function

Chih Hui Yang, Chih Yu Wang, Alexandru Mihai Grumezescu, Andrew H.J. Wang, Ching Ju Hsiao, Zu Yu Chen, Keng Shiang Huang

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


We report dual pH-responsive microcapsules manufactured by combining electrostatic droplets (ESD) and microfluidic droplets (MFD) techniques to produce monodisperse core (alginate)-shell (chitosan) structure with dual pH-responsive drug release function. The fabricated core-shell microcapsules were size controllable by tuning the synthesis parameters of the ESD and MFD systems, and were responsive in both acidic and alkaline environment, We used two model drugs (ampicillin loaded in the chitosan shell and diclofenac loaded in the alginate core) for drug delivery study. The results show that core-shell structure microcapsules have better drug release efficiency than respective core or shell particles. A biocompatibility test showed that the core-shell structure microcapsules presented positive cell viability (above 80%) when evaluated by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The results indicate that the synthesized core-shell microcapsules were a potential candidate of dual-drug carriers.

Original languageEnglish
Pages (from-to)2673-2680
Number of pages8
Issue number18
Publication statusPublished - Sept 2014
Externally publishedYes


  • Core-shell
  • Drug carriers
  • Drug release
  • Dual pH-responsive

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Clinical Biochemistry


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