Continuous production of dicarboxylic acid by immobilized Pseudomonas aeruginosa cells

Err Cheng Chan, Chin Sheng Cheng, Yuan Hsun Hsu

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Treatment of Pseudomonas aeruginosa with 3% (v/v) Tween 80 resulted in a 16-fold increase in the yield of conversion of n-pentadecane to the corresponding dioic acid, tridecane 1,13-dicarboxylic acid (DC-15). However, this conversion process was inhibited by high concentrations of DC-15. To avoid this product inhibition, a continuous process with immobilized cells was performed, and the results showed that the DC-15 yield was four-fold higher than in the case of batch type DC-15 production. The continuous process used in this study is adaptable to large-scale production of DC-15.

Original languageEnglish
Pages (from-to)157-160
Number of pages4
JournalJournal of Fermentation and Bioengineering
Issue number2
Publication statusPublished - 1997


  • 1,13-dicarboxylic acid
  • bioconversion
  • Pseudomonas aeruginosa

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology


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