Continuous Positive Airway Pressure Reduces Plasma Neurochemical Levels in Patients with OSA: A Pilot Study

Wen Te Liu, Huei Tyng Huang, Hsin Yi Hung, Shang Yang Lin, Wen Hua Hsu, Fang Yu Lee, Yi Chun Kuan, Yin Tzu Lin, Chia Rung Hsu, Marc Stettler, Chien Ming Yang, Jieni Wang, Ping Jung Duh, Kang Yun Lee, Dean Wu, Hsin Chien Lee, Jiunn Horng Kang, Szu Szu Lee, Hsiu Jui Wong, Cheng Yu TsaiArnab Majumdar

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Obstructive sleep apnea (OSA) is a risk factor for neurodegenerative diseases. This study determined whether continuous positive airway pressure (CPAP), which can alleviate OSA symptoms, can reduce neurochemical biomarker levels. Thirty patients with OSA and normal cognitive function were recruited and divided into the control (n = 10) and CPAP (n = 20) groups. Next, we examined their in-lab sleep data (polysomnography and CPAP titration), sleep-related questionnaire outcomes, and neurochemical biomarker levels at baseline and the 3-month follow-up. The paired t-test and Wilcoxon signed-rank test were used to examine changes. Analysis of covariance (ANCOVA) was performed to increase the robustness of outcomes. The Epworth Sleepiness Scale and Pittsburgh Sleep Quality Index scores were significantly decreased in the CPAP group. The mean levels of total tau (T-Tau), amyloid-beta-42 (Aβ42), and the product of the two (Aβ42 × T-Tau) increased considerably in the control group (ΔT-Tau: 2.31 pg/mL; ΔAβ42: 0.58 pg/mL; ΔAβ42 × T-Tau: 48.73 pg2/mL2), whereas the mean levels of T-Tau and the product of T-Tau and Aβ42 decreased considerably in the CPAP group (ΔT-Tau: −2.22 pg/mL; ΔAβ42 × T-Tau: −44.35 pg2/mL2). The results of ANCOVA with adjustment for age, sex, body mass index, baseline measurements, and apnea–hypopnea index demonstrated significant differences in neurochemical biomarker levels between the CPAP and control groups. The findings indicate that CPAP may reduce neurochemical biomarker levels by alleviating OSA symptoms.
Original languageEnglish
Article number613
JournalLife
Volume13
Issue number3
DOIs
Publication statusPublished - Feb 22 2023

Keywords

  • amyloid beta-peptide 42 (Aβ)
  • continuous positive airway pressure (CPAP)
  • neurodegenerative diseases
  • obstructive sleep apnea (OSA)
  • total tau (T-Tau)

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • General Biochemistry,Genetics and Molecular Biology
  • Space and Planetary Science
  • Palaeontology

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