Continuous Midazolam Infusion in the Treatment of Uncontrollable Neonatal Seizures

Kun Chieh Hu, Nan Chang Chiu, Che Sheng Ho, Sung Tse Lee, Ein Yiao Shen

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


A prospective open-label study was designed to determine the efficacy and safety of continuous midazolam infusion in neonates with uncontrollable neonatal seizures. Patients whose seizures could not be controlled by diazepam, phenytoin or phenobarbital were enrolled. Midazolam was given as an intravenous bolus dose followed by continuous intravenous infusion. Thirty-two patients fulfilled the inclusion criteria. Midazolam terminated the seizures in all patients. The maximum dose of midazolam ranged from 1 μg/kg/min to 15 μg/kg/min, with average of 4 μg/kg/min. Four patients had recurrent seizures, which stop after midazolam was reinstituted. There were no significant changes in serum sodium, potassium, calcium or glucose in any of the patients. Adverse effects included hypotension in 12 patients (38%) that was successfully controlled with inotropic agents (dopamine and/or dobutamine) and transient urinary retention in 12 (38%). Our study suggests that midazolam is safe and effective for the treatment of uncontrollable neonatal seizures.

Original languageEnglish
Pages (from-to)279-281
Number of pages3
JournalActa Paediatrica Taiwanica
Issue number5
Publication statusPublished - Sept 2003


  • Midazolam
  • Neonatal seizures
  • Uncontrollable seizures

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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