Continuous lumbar drainage after aneurysmal subarachnoid hemorrhage decreased malondialdehyde in cerebrospinal fluid and improved outcome

Yi Hsing Chen, Sheng Che Chou, Sung Chun Tang, Jing Er Lee, Jui Chang Tsai, Dar Ming Lai, Yong Kwang Tu, Sung Tsang Hsieh, Kuo Chuan Wang

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Purpose: The use of a continuous lumbar drain (LD) for the treatment of aneurysmal subarachnoid hemorrhage (aSAH), and malondialdehyde (MDA), a marker of oxidative stress, is correlated with clinical outcome. This study aimed to investigate the relationship between LD placement and MDA level after aSAH. Methods: Patients with modified Fisher's grade III and IV aSAH who underwent early aneurysm obliteration were enrolled. Cerebrospinal fluid (CSF) was obtained on day 7 after aSAH in non-LD group. In LD group, the LD was inserted on day 3 after aSAH for continuous CSF drainage. The levels of intrathecal hemoglobin, total bilirubin, ferritin, and MDA were measured. Results: There were 41 patients in non-LD group (age: 58.7 ± 13.7 years; female: 61.0%) and 48 patients in LD group (age: 58.3 ± 10.4 years; female: 79.2%). There were more favorable outcomes (Glasgow Outcome Scale ≥4) at 3 months after aSAH in LD group (p = 0.0042). The intrathecal hemoglobin, total bilirubin, ferritin, and MDA levels at day 7 after aSAH were all significantly lower in LD group. An older age (>60 years) (p = 0.0293), higher MDA level in the CSF (p = 0.0208), and delayed ischemic neurological deficit (p = 0.0451) were independent factors associated with unfavorable outcomes. LD placement was associated with a decreased intrathecal MDA level on day 7 after aSAH (p < 0.001). Conclusion: The intrathecal MDA level at day 7 after aSAH can be an effective outcome indicator in modified Fisher's grade III/IV aSAH. Continuous CSF drainage via a LD can decrease the intrathecal MDA level and improve the functional outcome.

Original languageEnglish
Pages (from-to)164-171
Number of pages8
JournalJournal of the Formosan Medical Association
Volume122
Issue number2
DOIs
Publication statusPublished - Feb 2023

Keywords

  • Aneurysmal subarachnoid hemorrhage
  • Cerebrospinal fluid
  • Delay ischemic neurological deficits
  • Lumbar drain
  • Malondialdehyde

ASJC Scopus subject areas

  • General Medicine

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