Construct Validity of the Quality of Life for Patients with Schizophrenia

Shu-Chun Lee, Jin-Ding Lin, En-Chi Chiu, For-Wey Lung

Research output: Contribution to journalArticlepeer-review


Objective: Health-related quality of life (HRQoL) has become one of the most valuable indicators of treatment in patients with schizophrenia. The purpose of this study was to establish the construct validity of eight domains in a HRQoL scale. Methods: From four psychiatric rehabilitation centers, 237 patients were chosen for participation in the study. Inclusion criteria were a DSM-IV-R diagnosis of schizophrenia. Quality of life was measured using the Quality of Life for Mental Disorders (QoLMD) scale. Structural equation modeling (SEM) was chosen to investigate the construct of the QoLMD. Results: This model of HRQoL for patients with schizophrenia was acceptable (Chi-square=1004.484 (df=789), p=0.192, GFI=0.852, RMSEA=0.034, TLI=0.940). The relationship between eight domains of the QoLMD can be interpretive into three parts: (A) under family support, patients with schizophrenia had significantly directly related to mental and physical health (β=0.849 and 0.738) and significantly indirectly related to HRQoL (i.e., life satisfaction, autonomy, health maintenance); (B) under physical health, schizophrenia patients had significantly directly related to HRQoL (β=0.745-0.921) (p<0.001); and (C) under mental health had significantly directly related to physical health (β=0.217) (p<0.05). Conclusion: The SEM revealed that HRQoL was interpreted by the pathways between eight domains of QoLMD, and therefore it made clinical therapists understood clearly about the correlation and mutual-influential pathway between HRQoL and QoLMD.
Translated title of the contribution精神分裂症病人生活品質量表之建構效度
Original languageEnglish
Pages (from-to)ii+16-26
Number of pages12
Issue number1
Publication statusPublished - Mar 2014
Externally publishedYes


  • health-related quality of life
  • severe and persistent mental illness
  • construct validity
  • structural equation modeling


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