Constituents of Polyalthia longifolia var. pendula

Zong-Huei Li; Mei Jhen Wang; Pi Yu Chen; Tung Ying Wu; Wu Che Wen; Fu Yu Tsai; Ching Kuo Lee

doi:10.1021/np900207z

Constituents of Polyalthia longifolia var. pendula

Zong-Huei Li, Mei Jhen Wang, Pi Yu Chen, Tung Ying Wu, Wu Che Wen, Fu Yu Tsai, Ching Kuo Lee

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

Three new clerodane-type diterpenes, 6R,16-dihydroxycleroda-3,13-dien-15- oic acid (1), 6α,16-dihydroxycleroda-4(18),13-dien-15-oic acid (2), and 4α,18β-epoxy-16-hydroxyclerod-13-en-15-oic acid (3), and four new protoberberine alkaloids, (-)-8-oxo-10-hydroxy-2,3,9-trimethoxyberberine (4), (-)-8-oxo-2,11-dihydroxy-3,10-dimethoxyberberine (5), (-)-8-oxo-11-hydroxy-2,3, 9,10-tetramethoxyberberine (6), and (-)-8-oxo-2,10-dihydroxy-3,9,11- trimethoxyberberine (7), together with 11 known substances, were isolated from a methanol extract of the stems of Polyalthia longifolia var. pendula. The structures of 1-7 were elucidated on the basis of spectroscopic data analysis. Compounds were evaluated for their antiproliferative activities against A549 and MCF-7 cancer cells, and among the substances tested, only 16-oxo-cleroda-3,13- dien-15-oic acid (8) exhibited cytotoxicity.

Original language	English
Pages (from-to)	1960-1963
Number of pages	4
Journal	Journal of Natural Products
Volume	72
Issue number	11
DOIs	https://doi.org/10.1021/np900207z
Publication status	Published - Nov 30 2009

ASJC Scopus subject areas

Drug Discovery
Analytical Chemistry
Molecular Medicine
Complementary and alternative medicine
Pharmacology
Pharmaceutical Science
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1021/np900207z

Cite this

@article{59d4aa4de9874a89bf7db420ce7705ab,

title = "Constituents of Polyalthia longifolia var. pendula",

abstract = "Three new clerodane-type diterpenes, 6R,16-dihydroxycleroda-3,13-dien-15- oic acid (1), 6α,16-dihydroxycleroda-4(18),13-dien-15-oic acid (2), and 4α,18β-epoxy-16-hydroxyclerod-13-en-15-oic acid (3), and four new protoberberine alkaloids, (-)-8-oxo-10-hydroxy-2,3,9-trimethoxyberberine (4), (-)-8-oxo-2,11-dihydroxy-3,10-dimethoxyberberine (5), (-)-8-oxo-11-hydroxy-2,3, 9,10-tetramethoxyberberine (6), and (-)-8-oxo-2,10-dihydroxy-3,9,11- trimethoxyberberine (7), together with 11 known substances, were isolated from a methanol extract of the stems of Polyalthia longifolia var. pendula. The structures of 1-7 were elucidated on the basis of spectroscopic data analysis. Compounds were evaluated for their antiproliferative activities against A549 and MCF-7 cancer cells, and among the substances tested, only 16-oxo-cleroda-3,13- dien-15-oic acid (8) exhibited cytotoxicity.",

author = "Zong-Huei Li and Wang, {Mei Jhen} and Chen, {Pi Yu} and Wu, {Tung Ying} and Wen, {Wu Che} and Tsai, {Fu Yu} and Lee, {Ching Kuo}",

year = "2009",

month = nov,

day = "30",

doi = "10.1021/np900207z",

language = "English",

volume = "72",

pages = "1960--1963",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "11",

}

TY - JOUR

T1 - Constituents of Polyalthia longifolia var. pendula

AU - Li, Zong-Huei

AU - Wang, Mei Jhen

AU - Chen, Pi Yu

AU - Wu, Tung Ying

AU - Wen, Wu Che

AU - Tsai, Fu Yu

AU - Lee, Ching Kuo

PY - 2009/11/30

Y1 - 2009/11/30

N2 - Three new clerodane-type diterpenes, 6R,16-dihydroxycleroda-3,13-dien-15- oic acid (1), 6α,16-dihydroxycleroda-4(18),13-dien-15-oic acid (2), and 4α,18β-epoxy-16-hydroxyclerod-13-en-15-oic acid (3), and four new protoberberine alkaloids, (-)-8-oxo-10-hydroxy-2,3,9-trimethoxyberberine (4), (-)-8-oxo-2,11-dihydroxy-3,10-dimethoxyberberine (5), (-)-8-oxo-11-hydroxy-2,3, 9,10-tetramethoxyberberine (6), and (-)-8-oxo-2,10-dihydroxy-3,9,11- trimethoxyberberine (7), together with 11 known substances, were isolated from a methanol extract of the stems of Polyalthia longifolia var. pendula. The structures of 1-7 were elucidated on the basis of spectroscopic data analysis. Compounds were evaluated for their antiproliferative activities against A549 and MCF-7 cancer cells, and among the substances tested, only 16-oxo-cleroda-3,13- dien-15-oic acid (8) exhibited cytotoxicity.

AB - Three new clerodane-type diterpenes, 6R,16-dihydroxycleroda-3,13-dien-15- oic acid (1), 6α,16-dihydroxycleroda-4(18),13-dien-15-oic acid (2), and 4α,18β-epoxy-16-hydroxyclerod-13-en-15-oic acid (3), and four new protoberberine alkaloids, (-)-8-oxo-10-hydroxy-2,3,9-trimethoxyberberine (4), (-)-8-oxo-2,11-dihydroxy-3,10-dimethoxyberberine (5), (-)-8-oxo-11-hydroxy-2,3, 9,10-tetramethoxyberberine (6), and (-)-8-oxo-2,10-dihydroxy-3,9,11- trimethoxyberberine (7), together with 11 known substances, were isolated from a methanol extract of the stems of Polyalthia longifolia var. pendula. The structures of 1-7 were elucidated on the basis of spectroscopic data analysis. Compounds were evaluated for their antiproliferative activities against A549 and MCF-7 cancer cells, and among the substances tested, only 16-oxo-cleroda-3,13- dien-15-oic acid (8) exhibited cytotoxicity.

UR - http://www.scopus.com/inward/record.url?scp=73349093429&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=73349093429&partnerID=8YFLogxK

U2 - 10.1021/np900207z

DO - 10.1021/np900207z

M3 - Article

C2 - 19860383

AN - SCOPUS:73349093429

SN - 0163-3864

VL - 72

SP - 1960

EP - 1963

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 11

ER -

Constituents of Polyalthia longifolia var. pendula

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this