Conn's Syndrome with an Unusual Presentation of Rhabdomyolysis Secondary to Severe Hypokalemia

Tien Hua Chuang, Chih Hsein Wang, Bo Yuan Tseng, Yung Hsiang Hsu, Jen Pi Tsai, Bang Gee Hsu, Te Chao Fang

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4 Citations (Scopus)


Conn's syndrome is one of the major causes of secondary hypertension. Premature hypertension, metabolic alkalosis, and hypokalemia usually lead clinicians to suspect the diagnosis. We describe a case of Conn's syndrome in a 28-year-old woman with an unusual presentation of rhabdomyolysis secondary to hypokalemia and complete bilateral lower limb paralysis. An elevated transtubular potassium concentration gradient, asymptomatic severe hypertension, and metabolic alkalosis pointed to possible primary hyperaldosteronism, which was confirmed by a decrease in plasma renin activity (PRA), elevation in plasma aldosterone level and elevation of the plasma aldosterone to PRA ratio. Computed tomography showed an adrenal tumor in the adrenal gland. Her blood pressure, hypokalemia, and plasma aldosterone level returned to normal after left adrenalectomy, further confirming the diagnosis. Histologic examination showed an adrenal gland adenoma.

Original languageEnglish
Pages (from-to)327-331
Number of pages5
JournalTzu Chi Medical Journal
Issue number4
Publication statusPublished - Dec 2008
Externally publishedYes


  • Conn's syndrome
  • Hypokalemia
  • Rhabdomyolysis

ASJC Scopus subject areas

  • Medicine(all)


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