Connection of Cancer Exosomal LncRNAs, Sponging miRNAs, and Exosomal Processing and Their Potential Modulation by Natural Products

Ya Ting Chuang, Jun Ping Shiau, Jen Yang Tang, Ammad Ahmad Farooqi, Fang Rong Chang, Yi Hong Tsai, Ching Yu Yen, Hsueh Wei Chang

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)

Abstract

Cancerous exosomes contain diverse biomolecules that regulate cancer progression. Modulating exosome biogenesis with clinical drugs has become an effective strategy for cancer therapy. Suppressing exosomal processing (assembly and secretion) may block exosomal function to reduce the proliferation of cancer cells. However, the information on natural products that modulate cancer exosomes lacks systemic organization, particularly for exosomal long noncoding RNAs (lncRNAs). There is a gap in the connection between exosomal lncRNAs and exosomal processing. This review introduces the database (LncTarD) to explore the potential of exosomal lncRNAs and their sponging miRNAs. The names of sponging miRNAs were transferred to the database (miRDB) for the target prediction of exosomal processing genes. Moreover, the impacts of lncRNAs, sponging miRNAs, and exosomal processing on the tumor microenvironment (TME) and natural-product-modulating anticancer effects were then retrieved and organized. This review sheds light on the functions of exosomal lncRNAs, sponging miRNAs, and exosomal processing in anticancer processes. It also provides future directions for the application of natural products when regulating cancerous exosomal lncRNAs.

Original languageEnglish
Article number2215
JournalCancers
Volume15
Issue number8
DOIs
Publication statusPublished - Apr 2023

Keywords

  • anticancer
  • exosomal processing
  • exosome
  • lncRNAs
  • natural product
  • sponging miRNAs

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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