Computer-aided diagnosis for identifying and delineating early gastric cancers in magnifying narrow-band imaging

Takashi Kanesaka, Tsung-Chun Lee, Noriya Uedo, Kun-Pei Lin, Huai-Zhe Chen, Ji-Yuh Lee, Hsiu-Po Wang, Hsuan Ting Chang

Research output: Contribution to journalArticlepeer-review


BACKGROUND AND AIMS: Magnifying narrow-band imaging (M-NBI) is important in the diagnosis of early gastric cancers (EGCs) but requires expertise to master. We developed a computer-aided diagnosis (CADx) system to assist endoscopists in identifying and delineating EGCs.

METHODS: We retrospectively collected and randomly selected 66 EGC M-NBI images and 60 non-cancer M-NBI images into a training set and 61 EGC M-NBI images and 20 non-cancer M-NBI images into a test set. After preprocessing and partition, we determined 8 gray-level co-occurrence matrix (GLCM) features for each partitioned 40 × 40 pixel block and calculated a coefficient of variation of 8 GLCM feature vectors. We then trained a support vector machine (SVMLv1) based on variation vectors from the training set and examined in the test set. Furthermore, we collected 2 determined P and Q GLCM feature vectors from cancerous image blocks containing irregular microvessels from the training set, and we trained another SVM (SVMLv2) to delineate cancerous blocks, which were compared with expert-delineated areas for area concordance.

RESULTS: The diagnostic performance revealed accuracy of 96.3%, precision (positive predictive value [PPV]) of 98.3%, recall (sensitivity) of 96.7%, and specificity of 95%, at a rate of 0.41 ± 0.01 seconds per image. The performance of area concordance, on a block basis, demonstrated accuracy of 73.8% ± 10.9%, precision (PPV) of 75.3% ± 20.9%, recall (sensitivity) of 65.5% ± 19.9%, and specificity of 80.8% ± 17.1%, at a rate of 0.49 ± 0.04 seconds per image.

CONCLUSIONS: This pilot study demonstrates that our CADx system has great potential in real-time diagnosis and delineation of EGCs in M-NBI images.

Original languageEnglish
Pages (from-to)1339-1344
Number of pages6
JournalGastrointestinal Endoscopy
Issue number5
Publication statusPublished - May 2018
Externally publishedYes


  • Aged
  • Case-Control Studies
  • Diagnosis, Computer-Assisted/methods
  • Early Detection of Cancer
  • Female
  • Gastroscopy/methods
  • Humans
  • Image Processing, Computer-Assisted/methods
  • Male
  • Middle Aged
  • Narrow Band Imaging/methods
  • Pilot Projects
  • Predictive Value of Tests
  • Retrospective Studies
  • Sensitivity and Specificity
  • Stomach Neoplasms/diagnostic imaging


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