Comprehensive analysis of prognostic significance of cadherin (CDH) gene family in breast cancer

Su Chi Ku, Hsin Liang Liu, Che Yu Su, I. Jeng Yeh, Meng Chi Yen, Gangga Anuraga, Hoang Dang Khoa Ta, Chung Chieh Chiao, Do Thi Minh Xuan, Fidelia Berenice Prayugo, Wei Jan Wang, Chih Yang Wang

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Breast cancer is one of the leading deaths in all kinds of malignancies; therefore, it is important for early detection. At the primary tumor site, tumor cells could take on mesenchymal properties, termed the epithelial-to-mesenchymal transition (EMT). This process is partly regulated by members of the cadherin (CDH) family of genes, and it is an essential step in the formation of metastases. There has been a lot of study of the roles of some of the CDH family genes in cancer; however, a holistic approach examining the roles of distinct CDH family genes in the development of breast cancer remains largely unexplored. In the present study, we used a bioinformatics approach to examine expression profiles of CDH family genes using the Oncomine, Gene Expression Profiling Interactive Analysis 2 (GEPIA2), cBioPortal, MetaCore, and Tumor IMmune Estimation Resource (TIMER) platforms. We revealed that CDH1/2/4/11/12/13 messenger (m)RNA levels are overexpressed in breast cancer cells compared to normal cells and were correlated with poor prognoses in breast cancer patients’ distant metastasis-free survival. An enrichment analysis showed that high expressions of CDH1/2/4/11/12/13 were significantly correlated with cell adhesion, the extracellular matrix remodeling process, the EMT, WNT/beta-catenin, and interleukin-mediated immune responses. Collectively, CDH1/2/4/11/12/13 are thought to be potential biomarkers for breast cancer progression and metastasis.

Original languageEnglish
Pages (from-to)8498-8567
Number of pages70
JournalAging
Volume14
Issue number20
DOIs
Publication statusPublished - 2022

Keywords

  • Bioinformatics
  • Breast cancer
  • Cadherin
  • Prognosis
  • Therapeutic targets

ASJC Scopus subject areas

  • Ageing
  • Cell Biology

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