Complete sequences of two plasmids in a blandm-1-positive klebsiella oxytoca isolate from taiwan

Tzu Wen Huang; Jann Tay Wang; Tsai Ling Lauderdale; Tsai Lien Liao; Jui Fen Lai; Mei Chen Tan; Ann Chi Lin; Ying Tsong Chen; Shih Feng Tsai; Shan Chwen Chang

doi:10.1128/AAC.02266-12

Complete sequences of two plasmids in a blandm-1-positive klebsiella oxytoca isolate from taiwan

Tzu Wen Huang, Jann Tay Wang, Tsai Ling Lauderdale, Tsai Lien Liao, Jui Fen Lai, Mei Chen Tan, Ann Chi Lin, Ying Tsong Chen, Shih Feng Tsai, Shan Chwen Chang

Research output: Contribution to journal › Article › peer-review

55 Citations (Scopus)

Abstract

Genetic determinants of a blaNDM-1-positive, multidrug-resistant bacterial isolate that caused active infection was investigated by DNA sequencing. Two plasmids, pKOX-NDM1 and pKOX-R1, were identified for the Klebsiella oxytoca strain E718. Sequence annotation revealed a blaNDM-1 gene in pKOX-NDM1 and two extended-spectrum-lactamase producers (blaCTX-M-3 and blaSHV-12) and a wide array of resistance genes in pKOX-R1. These findings highlight the difficulty in treating multidrugresistant bacterial infections and the potential danger of emerging resistant enterobacteria.

Original language	English
Pages (from-to)	4072-4076
Number of pages	5
Journal	Antimicrobial Agents and Chemotherapy
Volume	57
Issue number	8
DOIs	https://doi.org/10.1128/AAC.02266-12
Publication status	Published - Aug 2013
Externally published	Yes

ASJC Scopus subject areas

Pharmacology (medical)
Infectious Diseases
Pharmacology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/AAC.02266-12

Cite this

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title = "Complete sequences of two plasmids in a blandm-1-positive klebsiella oxytoca isolate from taiwan",

abstract = "Genetic determinants of a blaNDM-1-positive, multidrug-resistant bacterial isolate that caused active infection was investigated by DNA sequencing. Two plasmids, pKOX-NDM1 and pKOX-R1, were identified for the Klebsiella oxytoca strain E718. Sequence annotation revealed a blaNDM-1 gene in pKOX-NDM1 and two extended-spectrum-lactamase producers (blaCTX-M-3 and blaSHV-12) and a wide array of resistance genes in pKOX-R1. These findings highlight the difficulty in treating multidrugresistant bacterial infections and the potential danger of emerging resistant enterobacteria.",

author = "Huang, {Tzu Wen} and Wang, {Jann Tay} and Lauderdale, {Tsai Ling} and Liao, {Tsai Lien} and Lai, {Jui Fen} and Tan, {Mei Chen} and Lin, {Ann Chi} and Chen, {Ying Tsong} and Tsai, {Shih Feng} and Chang, {Shan Chwen}",

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doi = "10.1128/AAC.02266-12",

language = "English",

volume = "57",

pages = "4072--4076",

journal = "Antimicrobial Agents and Chemotherapy",

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publisher = "American Society for Microbiology",

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T1 - Complete sequences of two plasmids in a blandm-1-positive klebsiella oxytoca isolate from taiwan

AU - Huang, Tzu Wen

AU - Wang, Jann Tay

AU - Lauderdale, Tsai Ling

AU - Liao, Tsai Lien

AU - Lai, Jui Fen

AU - Tan, Mei Chen

AU - Lin, Ann Chi

AU - Chen, Ying Tsong

AU - Tsai, Shih Feng

AU - Chang, Shan Chwen

PY - 2013/8

Y1 - 2013/8

N2 - Genetic determinants of a blaNDM-1-positive, multidrug-resistant bacterial isolate that caused active infection was investigated by DNA sequencing. Two plasmids, pKOX-NDM1 and pKOX-R1, were identified for the Klebsiella oxytoca strain E718. Sequence annotation revealed a blaNDM-1 gene in pKOX-NDM1 and two extended-spectrum-lactamase producers (blaCTX-M-3 and blaSHV-12) and a wide array of resistance genes in pKOX-R1. These findings highlight the difficulty in treating multidrugresistant bacterial infections and the potential danger of emerging resistant enterobacteria.

AB - Genetic determinants of a blaNDM-1-positive, multidrug-resistant bacterial isolate that caused active infection was investigated by DNA sequencing. Two plasmids, pKOX-NDM1 and pKOX-R1, were identified for the Klebsiella oxytoca strain E718. Sequence annotation revealed a blaNDM-1 gene in pKOX-NDM1 and two extended-spectrum-lactamase producers (blaCTX-M-3 and blaSHV-12) and a wide array of resistance genes in pKOX-R1. These findings highlight the difficulty in treating multidrugresistant bacterial infections and the potential danger of emerging resistant enterobacteria.

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Complete sequences of two plasmids in a blandm-1-positive klebsiella oxytoca isolate from taiwan

Abstract

ASJC Scopus subject areas

UN SDGs

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