Compatibility and osmolality of inhaled N-acetylcysteine nebulizing solution with fenoterol and ipratropium

Tzung Yi Lee, Chi Ming Chen, Chun Nin Lee, Yi Chun Chiang, Hsiang Yin Chen

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Purpose. The compatibility, pH, and osmolality of N-acetylcysteine (NAC) nebulizing solution in the presence of ipratropium bromide or fenoterol hydrobromide were studied. Methods. Portions (400 μL) of each mixture were sampled immediately upon mixing and one, two, three, four, five, six, and seven hours after mixing and assayed by high-performance liquid chromatography. Osmolality was measured by sampling 100 μL from the filling cup at a five-minute interval during nebulization and by the freezing-point-depression method. Results. Adding NAC solution to fenoterol solution raised the pH from 3.20 to 7.90 and the osmolality to a mean ± S.D. of 1400.67 ± 4.51 mOsm/kg. Fenoterol concentrations decreased to 93.71% and NAC concentrations to 92.54% of initial concentrations after seven hours. Mixing ipratropium with NAC solution raised the pH from 3.74 to 7.95 and the osmolality to a mean ± S.D. of 1413 ± 11.79 mOsm/kg. The initial ipratropiom concentration declined 7.39% and 10.91% one and two hours after mixing with NAC solution, respectively. Conclusion. NAC and ipratropium were stable in nebulizing solution within one hour of mixing. NAC and fenoterol were compatible for at least seven hours.

Original languageEnglish
Pages (from-to)828-833
Number of pages6
JournalAmerican Journal of Health-System Pharmacy
Issue number8
Publication statusPublished - Apr 15 2005


  • Acetylcysteine
  • Concentration
  • Fenoterol hydrobromide
  • Hydrogen ion concentration
  • Incompatibilities
  • Ipratroplum bromide
  • Mucolytic agents
  • Nebulizers
  • Osmolality
  • Parasympatholytic agents
  • Stability
  • Storage
  • Sympathomimetic agents

ASJC Scopus subject areas

  • Pharmacy
  • Pharmacology
  • Health Policy


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