Comparisons of clinical impacts on individuals with Brugada electrocardiographic patterns defined by ISHNE criteria or EHRA/HRS/APHRS criteria: a nationwide community-based study

Ching Yu Julius Chen; Jyh Ming Jimmy Juang; Ying Hsiang Chen; I. Chien Wu; Chih Cheng Hsu; Ray Chin Wu; Kwo Ching Chen; Wen Jin Liaw; Tsung Lung Tsai; Lian Yu Lin; Juey Jen Hwang; Li Ting Ho; Chih Chien Yu; Jen Kuang Lee; Cho Kai Wu; Shih Fan Sherri Yeh; Dun Hui Yang; I. Shou Chang; Ling Ping Lai; Fu Tien Chiang; Jiunn Lee Lin; Chao Agnes Hsiung

doi:10.1080/07853890.2017.1353222

Comparisons of clinical impacts on individuals with Brugada electrocardiographic patterns defined by ISHNE criteria or EHRA/HRS/APHRS criteria: a nationwide community-based study

Ching Yu Julius Chen, Jyh Ming Jimmy Juang, Ying Hsiang Chen, I. Chien Wu, Chih Cheng Hsu, Ray Chin Wu, Kwo Ching Chen, Wen Jin Liaw, Tsung Lung Tsai, Lian Yu Lin, Juey Jen Hwang, Li Ting Ho, Chih Chien Yu, Jen Kuang Lee, Cho Kai Wu, Shih Fan Sherri Yeh, Dun Hui Yang, I. Shou Chang, Ling Ping Lai, Fu Tien ChiangJiunn Lee Lin, Chao Agnes Hsiung

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Introduction: Identifying Brugada electrocardiographic pattern (BrP) early is crucial to prevent sudden cardiac death. Two different diagnostic criteria proposed by International Society for Holter and Noninvasive Electrocardiography (ISHNE) and Heart Rhythm Society/European Heart Rhythm Association/Asia-Pacific Heart Rhythm Society (HRS/EHRA/APHRS) were widely used in clinical practice. The difference in prevalence and prognosis of BrP by applying the two different criteria was never studied before. Methods: This study was prospectively conducted in a nationwide large-scale stratified random sampling community-based cohort (HALST) from Han Chinese population in Taiwan from December 2008 to December 2012. We compared the prevalence and prognosis of BrP defined by the two diagnostic criteria. Results: A total of 5214 adults were enrolled (2530 men) with mean age of 69.3 years. Four had spontaneous type 1 BrP (0.077%). By the HRS/EHRA/APHRS criteria, 68 individuals have type 2 BrP (1.30%) and 101 have type 3 BrP (1.94%) whereas by the ISHNE criteria, 46 individuals exhibited type 2 BrP (0.88%). When applying the ISHNE criteria, the number of individuals with BrP decreased by 71%. However, all-cause mortality and cardiovascular mortality were not different between individuals with or without BrP, irrespective of the criteria used. Conclusions: The two different criteria may impact the diagnostic yield of individuals with BrP, but do not affect the prognosis of the individuals with BrP.Key messages Comparing with the use of HRS/EHRA/APHRS criteria, the number of individuals with Brugada ECG patterns was decreased by 71% when applying the ISHNE criteria. The prognosis of individuals with Brugada ECG patterns defined by 2012 ISHNE or 2013 HRS/EHRA/APHRS criteria were not different.

Original language	English
Pages (from-to)	7-15
Number of pages	9
Journal	Annals of Medicine
Volume	50
Issue number	1
DOIs	https://doi.org/10.1080/07853890.2017.1353222
Publication status	Published - Jan 2 2018
Externally published	Yes

Keywords

Brugada electrocardiographic patterns
community-based
Han Chinese population
long-term prognosis
Prevalence

ASJC Scopus subject areas

General Medicine

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10.1080/07853890.2017.1353222

Cite this

Chen, C. Y. J., Juang, J. M. J., Chen, Y. H., Wu, I. C., Hsu, C. C., Wu, R. C., Chen, K. C., Liaw, W. J., Tsai, T. L., Lin, L. Y., Hwang, J. J., Ho, L. T., Yu, C. C., Lee, J. K., Wu, C. K., Yeh, S. F. S., Yang, D. H., Chang, I. S., Lai, L. P., ... Hsiung, C. A. (2018). Comparisons of clinical impacts on individuals with Brugada electrocardiographic patterns defined by ISHNE criteria or EHRA/HRS/APHRS criteria: a nationwide community-based study. Annals of Medicine, 50(1), 7-15. https://doi.org/10.1080/07853890.2017.1353222

Comparisons of clinical impacts on individuals with Brugada electrocardiographic patterns defined by ISHNE criteria or EHRA/HRS/APHRS criteria: a nationwide community-based study. / Chen, Ching Yu Julius; Juang, Jyh Ming Jimmy; Chen, Ying Hsiang et al.
In: Annals of Medicine, Vol. 50, No. 1, 02.01.2018, p. 7-15.

Research output: Contribution to journal › Article › peer-review

Chen, CYJ, Juang, JMJ, Chen, YH, Wu, IC, Hsu, CC, Wu, RC, Chen, KC, Liaw, WJ, Tsai, TL, Lin, LY, Hwang, JJ, Ho, LT, Yu, CC, Lee, JK, Wu, CK, Yeh, SFS, Yang, DH, Chang, IS, Lai, LP, Chiang, FT, Lin, JL & Hsiung, CA 2018, 'Comparisons of clinical impacts on individuals with Brugada electrocardiographic patterns defined by ISHNE criteria or EHRA/HRS/APHRS criteria: a nationwide community-based study', Annals of Medicine, vol. 50, no. 1, pp. 7-15. https://doi.org/10.1080/07853890.2017.1353222

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title = "Comparisons of clinical impacts on individuals with Brugada electrocardiographic patterns defined by ISHNE criteria or EHRA/HRS/APHRS criteria: a nationwide community-based study",

abstract = "Introduction: Identifying Brugada electrocardiographic pattern (BrP) early is crucial to prevent sudden cardiac death. Two different diagnostic criteria proposed by International Society for Holter and Noninvasive Electrocardiography (ISHNE) and Heart Rhythm Society/European Heart Rhythm Association/Asia-Pacific Heart Rhythm Society (HRS/EHRA/APHRS) were widely used in clinical practice. The difference in prevalence and prognosis of BrP by applying the two different criteria was never studied before. Methods: This study was prospectively conducted in a nationwide large-scale stratified random sampling community-based cohort (HALST) from Han Chinese population in Taiwan from December 2008 to December 2012. We compared the prevalence and prognosis of BrP defined by the two diagnostic criteria. Results: A total of 5214 adults were enrolled (2530 men) with mean age of 69.3 years. Four had spontaneous type 1 BrP (0.077%). By the HRS/EHRA/APHRS criteria, 68 individuals have type 2 BrP (1.30%) and 101 have type 3 BrP (1.94%) whereas by the ISHNE criteria, 46 individuals exhibited type 2 BrP (0.88%). When applying the ISHNE criteria, the number of individuals with BrP decreased by 71%. However, all-cause mortality and cardiovascular mortality were not different between individuals with or without BrP, irrespective of the criteria used. Conclusions: The two different criteria may impact the diagnostic yield of individuals with BrP, but do not affect the prognosis of the individuals with BrP.Key messages Comparing with the use of HRS/EHRA/APHRS criteria, the number of individuals with Brugada ECG patterns was decreased by 71% when applying the ISHNE criteria. The prognosis of individuals with Brugada ECG patterns defined by 2012 ISHNE or 2013 HRS/EHRA/APHRS criteria were not different.",

keywords = "Brugada electrocardiographic patterns, community-based, Han Chinese population, long-term prognosis, Prevalence",

author = "Chen, {Ching Yu Julius} and Juang, {Jyh Ming Jimmy} and Chen, {Ying Hsiang} and Wu, {I. Chien} and Hsu, {Chih Cheng} and Wu, {Ray Chin} and Chen, {Kwo Ching} and Liaw, {Wen Jin} and Tsai, {Tsung Lung} and Lin, {Lian Yu} and Hwang, {Juey Jen} and Ho, {Li Ting} and Yu, {Chih Chien} and Lee, {Jen Kuang} and Wu, {Cho Kai} and Yeh, {Shih Fan Sherri} and Yang, {Dun Hui} and Chang, {I. Shou} and Lai, {Ling Ping} and Chiang, {Fu Tien} and Lin, {Jiunn Lee} and Hsiung, {Chao Agnes}",

note = "Publisher Copyright: {\textcopyright} 2017 Informa UK Limited, trading as Taylor & Francis Group.",

year = "2018",

month = jan,

day = "2",

doi = "10.1080/07853890.2017.1353222",

language = "English",

volume = "50",

pages = "7--15",

journal = "Annals of Medicine",

issn = "0785-3890",

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TY - JOUR

T1 - Comparisons of clinical impacts on individuals with Brugada electrocardiographic patterns defined by ISHNE criteria or EHRA/HRS/APHRS criteria

T2 - a nationwide community-based study

AU - Chen, Ching Yu Julius

AU - Juang, Jyh Ming Jimmy

AU - Chen, Ying Hsiang

AU - Wu, I. Chien

AU - Hsu, Chih Cheng

AU - Wu, Ray Chin

AU - Chen, Kwo Ching

AU - Liaw, Wen Jin

AU - Tsai, Tsung Lung

AU - Lin, Lian Yu

AU - Hwang, Juey Jen

AU - Ho, Li Ting

AU - Yu, Chih Chien

AU - Lee, Jen Kuang

AU - Wu, Cho Kai

AU - Yeh, Shih Fan Sherri

AU - Yang, Dun Hui

AU - Chang, I. Shou

AU - Lai, Ling Ping

AU - Chiang, Fu Tien

AU - Lin, Jiunn Lee

AU - Hsiung, Chao Agnes

PY - 2018/1/2

Y1 - 2018/1/2

N2 - Introduction: Identifying Brugada electrocardiographic pattern (BrP) early is crucial to prevent sudden cardiac death. Two different diagnostic criteria proposed by International Society for Holter and Noninvasive Electrocardiography (ISHNE) and Heart Rhythm Society/European Heart Rhythm Association/Asia-Pacific Heart Rhythm Society (HRS/EHRA/APHRS) were widely used in clinical practice. The difference in prevalence and prognosis of BrP by applying the two different criteria was never studied before. Methods: This study was prospectively conducted in a nationwide large-scale stratified random sampling community-based cohort (HALST) from Han Chinese population in Taiwan from December 2008 to December 2012. We compared the prevalence and prognosis of BrP defined by the two diagnostic criteria. Results: A total of 5214 adults were enrolled (2530 men) with mean age of 69.3 years. Four had spontaneous type 1 BrP (0.077%). By the HRS/EHRA/APHRS criteria, 68 individuals have type 2 BrP (1.30%) and 101 have type 3 BrP (1.94%) whereas by the ISHNE criteria, 46 individuals exhibited type 2 BrP (0.88%). When applying the ISHNE criteria, the number of individuals with BrP decreased by 71%. However, all-cause mortality and cardiovascular mortality were not different between individuals with or without BrP, irrespective of the criteria used. Conclusions: The two different criteria may impact the diagnostic yield of individuals with BrP, but do not affect the prognosis of the individuals with BrP.Key messages Comparing with the use of HRS/EHRA/APHRS criteria, the number of individuals with Brugada ECG patterns was decreased by 71% when applying the ISHNE criteria. The prognosis of individuals with Brugada ECG patterns defined by 2012 ISHNE or 2013 HRS/EHRA/APHRS criteria were not different.

AB - Introduction: Identifying Brugada electrocardiographic pattern (BrP) early is crucial to prevent sudden cardiac death. Two different diagnostic criteria proposed by International Society for Holter and Noninvasive Electrocardiography (ISHNE) and Heart Rhythm Society/European Heart Rhythm Association/Asia-Pacific Heart Rhythm Society (HRS/EHRA/APHRS) were widely used in clinical practice. The difference in prevalence and prognosis of BrP by applying the two different criteria was never studied before. Methods: This study was prospectively conducted in a nationwide large-scale stratified random sampling community-based cohort (HALST) from Han Chinese population in Taiwan from December 2008 to December 2012. We compared the prevalence and prognosis of BrP defined by the two diagnostic criteria. Results: A total of 5214 adults were enrolled (2530 men) with mean age of 69.3 years. Four had spontaneous type 1 BrP (0.077%). By the HRS/EHRA/APHRS criteria, 68 individuals have type 2 BrP (1.30%) and 101 have type 3 BrP (1.94%) whereas by the ISHNE criteria, 46 individuals exhibited type 2 BrP (0.88%). When applying the ISHNE criteria, the number of individuals with BrP decreased by 71%. However, all-cause mortality and cardiovascular mortality were not different between individuals with or without BrP, irrespective of the criteria used. Conclusions: The two different criteria may impact the diagnostic yield of individuals with BrP, but do not affect the prognosis of the individuals with BrP.Key messages Comparing with the use of HRS/EHRA/APHRS criteria, the number of individuals with Brugada ECG patterns was decreased by 71% when applying the ISHNE criteria. The prognosis of individuals with Brugada ECG patterns defined by 2012 ISHNE or 2013 HRS/EHRA/APHRS criteria were not different.

KW - Brugada electrocardiographic patterns

KW - community-based

KW - Han Chinese population

KW - long-term prognosis

KW - Prevalence

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Comparisons of clinical impacts on individuals with Brugada electrocardiographic patterns defined by ISHNE criteria or EHRA/HRS/APHRS criteria: a nationwide community-based study

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