Comparison of serum CA72-4, CEA, TPA, CA19-9 and CA125 levels in gastric cancer patients and correlation with recurrence

I. Rue Lai, Wei Jei Lee, Ming Te Huang, Hshu Hshing Lin

Research output: Contribution to journalArticlepeer-review

80 Citations (Scopus)


Background/Aims: Serum tumor markers were investigated as prognostic factors for recurrence in patients with gastric cancers. Methodology: Preoperative serum levels of CEA, CA72-4, CA19-9, TPA and CA125 were sampled in 196 patients with gastric cancers undergoing curative surgery. The results were compared with the clinical recurrence and various clinicopathological factors. Results: CA72-4, CEA, CA19-9, TPA and CA125 had sensitivities of 16.4%, 31.4%, 16.1%, 31.6%, and 6%, respectively. Sensitivity of two combinations was as high as 56.5%. Seventy-seven patients (39.9%) had clinical recurrence in the follow-up periods. For those with preoperatively elevated serum tumor markers, 38% (12/32) had CA72-4, 42% (13/31) had CA19-9, 48% (29/60) and had CEA, 54% (6/11) had CA125, and 62% (37/61) had TPA, and remained disease-free. Univariate analysis showed that TNM staging, Tumor size, Borrmann classification of tumor growth, and preoperative serum CA72-4 level were correlated with recurrence of disease. Multivariate analysis showed that independent prognostic factor of recurrence was TNM staging (P=0.0007). Conclusions: Preoperative serum CA72-4 level is correlated with staging of disease, but is not an independent predictor for clinical recurrence of disease in patients with gastric cancers that undergo surgery.

Original languageEnglish
Pages (from-to)1157-1160
Number of pages4
Issue number46
Publication statusPublished - 2002
Externally publishedYes


  • CA72-4
  • Gastric cancer

ASJC Scopus subject areas

  • Gastroenterology


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