Comparison of oral glucose insulin sensitivity with other insulin sensitivity surrogates from oral glucose tolerance tests in Chinese

Introduction: There is no single method of measuring insulin resistance that is both accurate and can be easily performed by general researchers. We validate the accuracy of oral glucose insulin sensitivity (OGIS) in the Chinese by comparing the OGIS₁₂₀ and OGIS₁₈₀, homeostasis model assessment of insulin resistance (HOMA-IR), and quantitative insulin sensitivity check index (OUICKI) with steady-state plasma glucose (SSPG) in different glucose tolerance subjects. Materials and Methods: We enrolled 515 subjects, aged between 20 and 75 years old, during routine health evaluations. All subjects were divided into normal, obese, impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and type 2 diabetes (T2D) groups. Participants had a 3-hour oral glucose tolerance test (OGTT) and SSPG with an insulin suppression test. The relationships between SSPG and OGIS₁₂₀, OGIS₁₈₀, HOMA-IR, and QUICKI were evaluated. Results: The normal group had the highest OGIS₁₂₀, OGIS₁₈₀ and lowest SSPG as compared with the other 4 groups. OGIS₁₈₀, HOMA-IR and QUICKI in all 5 groups were significantly related to SSPG (r = 0.397-0.621, all P 120 in all 5 groups was not significantly related to SSPG (r = 0.003-0.226). Additionally, the r value of OGIS₁₈₀ against SSPG was not higher than the other 2 insulin sensitivity surrogates from OGTT. Conclusions: Although OGIS₁₈₀ was more accurate in estimating insulin sensitivity than OGIS₁₂₀ in the Chinese, it was not superior to the traditional surrogates such as HOMA-IR or QUICKI.