Comparison of Intravenous and Enteral Indomethacin Administration for Closure of Patent Ductus Arteriosus in Extremely-low-birth-weight Infants

Pei Chen Tsao; Shu Jen Chen; Chia Feng Yang; Yu Sheng Lee; Mei Jy Jeng; Wen Jue Soong; Pi Chang Lee; Jen Her Lu; Betau Hwang; Ren Bin Tang

doi:10.1016/S1726-4901(10)70016-2

Comparison of Intravenous and Enteral Indomethacin Administration for Closure of Patent Ductus Arteriosus in Extremely-low-birth-weight Infants

Pei Chen Tsao, Shu Jen Chen, Chia Feng Yang, Yu Sheng Lee, Mei Jy Jeng, Wen Jue Soong, Pi Chang Lee, Jen Her Lu, Betau Hwang, Ren Bin Tang

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Background: The objective of this retrospective cohort study was to compare the patent ductus arteriosus (PDA) closure rate with different routes (intravenous and enteral) of indomethacin treatment and neonatal outcomes. Methods: Infants with a birthweight < 1,000 g born between July 1997 and June 2007 at Taipei Veterans General Hospital and who received indomethacin treatment for PDA were included in the study. Outcome measures were ductal closure rate and neonatal outcomes. Results: Of 41 extremely-low-birth-weight infants with PDA, 3 infants had spontaneous closure and 3 died before treatment. Of the remaining 35 infants, 13 received enteral ethanol solution of indomethacin and 22 received the intravenous (IV) form. The total closure rates of the IV and enteral groups were 81.8% and 76.9%, respectively. There were no significant differences in the incidence of impaired renal function, necrotizing enterocolitis, chronic lung disease or severe retinopathy of prematurity between the 2 groups. Conclusion: Our results suggest that ethanol-based indomethacin is an effective alternative to IV indomethacin for the pharmacological closure of PDA in extremely-low-birth-weight infants.

Original language	English
Pages (from-to)	15-20
Number of pages	6
Journal	Journal of the Chinese Medical Association
Volume	73
Issue number	1
DOIs	https://doi.org/10.1016/S1726-4901(10)70016-2
Publication status	Published - Jan 2010
Externally published	Yes

Keywords

enteral route
indomethacin
patent ductus arteriosus
preterm

ASJC Scopus subject areas

General Medicine

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10.1016/S1726-4901(10)70016-2

Cite this

Tsao, P. C., Chen, S. J., Yang, C. F., Lee, Y. S., Jeng, M. J., Soong, W. J., Lee, P. C., Lu, J. H., Hwang, B., & Tang, R. B. (2010). Comparison of Intravenous and Enteral Indomethacin Administration for Closure of Patent Ductus Arteriosus in Extremely-low-birth-weight Infants. Journal of the Chinese Medical Association, 73(1), 15-20. https://doi.org/10.1016/S1726-4901(10)70016-2

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title = "Comparison of Intravenous and Enteral Indomethacin Administration for Closure of Patent Ductus Arteriosus in Extremely-low-birth-weight Infants",

abstract = "Background: The objective of this retrospective cohort study was to compare the patent ductus arteriosus (PDA) closure rate with different routes (intravenous and enteral) of indomethacin treatment and neonatal outcomes. Methods: Infants with a birthweight < 1,000 g born between July 1997 and June 2007 at Taipei Veterans General Hospital and who received indomethacin treatment for PDA were included in the study. Outcome measures were ductal closure rate and neonatal outcomes. Results: Of 41 extremely-low-birth-weight infants with PDA, 3 infants had spontaneous closure and 3 died before treatment. Of the remaining 35 infants, 13 received enteral ethanol solution of indomethacin and 22 received the intravenous (IV) form. The total closure rates of the IV and enteral groups were 81.8% and 76.9%, respectively. There were no significant differences in the incidence of impaired renal function, necrotizing enterocolitis, chronic lung disease or severe retinopathy of prematurity between the 2 groups. Conclusion: Our results suggest that ethanol-based indomethacin is an effective alternative to IV indomethacin for the pharmacological closure of PDA in extremely-low-birth-weight infants.",

keywords = "enteral route, indomethacin, patent ductus arteriosus, preterm",

author = "Tsao, {Pei Chen} and Chen, {Shu Jen} and Yang, {Chia Feng} and Lee, {Yu Sheng} and Jeng, {Mei Jy} and Soong, {Wen Jue} and Lee, {Pi Chang} and Lu, {Jen Her} and Betau Hwang and Tang, {Ren Bin}",

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doi = "10.1016/S1726-4901(10)70016-2",

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AU - Chen, Shu Jen

AU - Yang, Chia Feng

AU - Lee, Yu Sheng

AU - Jeng, Mei Jy

AU - Soong, Wen Jue

AU - Lee, Pi Chang

AU - Lu, Jen Her

AU - Hwang, Betau

AU - Tang, Ren Bin

PY - 2010/1

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N2 - Background: The objective of this retrospective cohort study was to compare the patent ductus arteriosus (PDA) closure rate with different routes (intravenous and enteral) of indomethacin treatment and neonatal outcomes. Methods: Infants with a birthweight < 1,000 g born between July 1997 and June 2007 at Taipei Veterans General Hospital and who received indomethacin treatment for PDA were included in the study. Outcome measures were ductal closure rate and neonatal outcomes. Results: Of 41 extremely-low-birth-weight infants with PDA, 3 infants had spontaneous closure and 3 died before treatment. Of the remaining 35 infants, 13 received enteral ethanol solution of indomethacin and 22 received the intravenous (IV) form. The total closure rates of the IV and enteral groups were 81.8% and 76.9%, respectively. There were no significant differences in the incidence of impaired renal function, necrotizing enterocolitis, chronic lung disease or severe retinopathy of prematurity between the 2 groups. Conclusion: Our results suggest that ethanol-based indomethacin is an effective alternative to IV indomethacin for the pharmacological closure of PDA in extremely-low-birth-weight infants.

AB - Background: The objective of this retrospective cohort study was to compare the patent ductus arteriosus (PDA) closure rate with different routes (intravenous and enteral) of indomethacin treatment and neonatal outcomes. Methods: Infants with a birthweight < 1,000 g born between July 1997 and June 2007 at Taipei Veterans General Hospital and who received indomethacin treatment for PDA were included in the study. Outcome measures were ductal closure rate and neonatal outcomes. Results: Of 41 extremely-low-birth-weight infants with PDA, 3 infants had spontaneous closure and 3 died before treatment. Of the remaining 35 infants, 13 received enteral ethanol solution of indomethacin and 22 received the intravenous (IV) form. The total closure rates of the IV and enteral groups were 81.8% and 76.9%, respectively. There were no significant differences in the incidence of impaired renal function, necrotizing enterocolitis, chronic lung disease or severe retinopathy of prematurity between the 2 groups. Conclusion: Our results suggest that ethanol-based indomethacin is an effective alternative to IV indomethacin for the pharmacological closure of PDA in extremely-low-birth-weight infants.

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Comparison of Intravenous and Enteral Indomethacin Administration for Closure of Patent Ductus Arteriosus in Extremely-low-birth-weight Infants

Abstract

Keywords

ASJC Scopus subject areas

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