Comparison of human and chimpanzee ξ1 blobin genes

Cary Willard, Elsie Wong, John F. Hess, Che Kun James Shen, Barbara Chapman, Allan C. Wilson, Carl W. Schmid

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


The DNA base sequences of the entire chimpanzee ξ1 globin gene and an additional 1 kb of DNA flanking both the human and chimpanzee genes have been determined. Whereas the human ξ1 gene contains a termination codon in the sixth position, the chimpanzee gene appears to be functional. This finding confirms Proudfoot et al.'s suggestion that the human ξ1 gene was recently inactivated. Like the corresponding human ξ1 and ξ2 genes, the first and second introns of the chimpanzee ξ1 gene are occupied largely by tandem repeats of short oligonucleotides. These tandem repeats have undergone several rearrangements since the divergence of the human and chimpanzee ξ1 genes.

Original languageEnglish
Pages (from-to)309-315
Number of pages7
JournalJournal of Molecular Evolution
Issue number4
Publication statusPublished - Dec 1985
Externally publishedYes


  • Globin genes
  • Primate evolution
  • Tandem repeats

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics


Dive into the research topics of 'Comparison of human and chimpanzee ξ1 blobin genes'. Together they form a unique fingerprint.

Cite this