Comparison of escitalopram and paroxetine in the treatment of major depressive disorder

Huang Li Lin; Ya Ting Hsu; Chia Yih Liu; Chia Hui Chen; Mei Chun Hsiao; Yu Li Liu; Winston W. Shen; Chin Fu Hsiao; Shen Ing Liu; Liang Huey Chang; Hwa Sheng Tang; Hsiang Ling Lai; Pei Sheng Lin; Keh Ming Lin; Hsiao Hui Tsou

doi:10.1097/YIC.0b013e32836458e2

Comparison of escitalopram and paroxetine in the treatment of major depressive disorder

Huang Li Lin, Ya Ting Hsu, Chia Yih Liu, Chia Hui Chen, Mei Chun Hsiao, Yu Li Liu, Winston W. Shen, Chin Fu Hsiao, Shen Ing Liu, Liang Huey Chang, Hwa Sheng Tang, Hsiang Ling Lai, Pei Sheng Lin, Keh Ming Lin, Hsiao Hui Tsou

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

This is a single-blind, parallel, flexible-dose study to compare the efficacy and tolerability of escitalopram and paroxetine in the treatment of patients with major depressive disorder. We recruited 399 patients from the outpatient clinics of five hospitals in northern Taiwan. Patients were administered either escitalopram (10-30 mg) or paroxetine (20-40 mg) according to the judgment of clinicians. These patients were assessed using the Hamilton Rating Scale for Depression (HAM-D) and the Hamilton Rating Scale for Anxiety at weeks 0, 1, 2, 4, 6, and 8. A total of 302 patients fulfilled the evaluation criteria and were included in a statistical analysis. We found that escitalopram induced more significant symptom reduction and response rate in terms of the mean HAM-D scores at week 6 (P

Original language	English
Pages (from-to)	339-345
Number of pages	7
Journal	International Clinical Psychopharmacology
Volume	28
Issue number	6
DOIs	https://doi.org/10.1097/YIC.0b013e32836458e2
Publication status	Published - Nov 2013

Keywords

Depression
Efficacy
Escitalopram
Paroxetine

ASJC Scopus subject areas

Psychiatry and Mental health
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/YIC.0b013e32836458e2

Cite this

Lin, H. L., Hsu, Y. T., Liu, C. Y., Chen, C. H., Hsiao, M. C., Liu, Y. L., Shen, W. W., Hsiao, C. F., Liu, S. I., Chang, L. H., Tang, H. S., Lai, H. L., Lin, P. S., Lin, K. M., & Tsou, H. H. (2013). Comparison of escitalopram and paroxetine in the treatment of major depressive disorder. International Clinical Psychopharmacology, 28(6), 339-345. https://doi.org/10.1097/YIC.0b013e32836458e2

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AU - Liu, Yu Li

AU - Shen, Winston W.

AU - Hsiao, Chin Fu

AU - Liu, Shen Ing

AU - Chang, Liang Huey

AU - Tang, Hwa Sheng

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AU - Lin, Pei Sheng

AU - Lin, Keh Ming

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Comparison of escitalopram and paroxetine in the treatment of major depressive disorder

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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