Comparison of coasting and intravenous albumin in the prevention of ovarian hyperstimulation syndrome

Chin Der Chen, Kuang Han Chao, Jehn Hsiahn Yang, Shee Uan Chen, Hong Nerng Ho, Yu Shih Yang

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)


Objective: To compare the efficacy of coasting to prevent ovarian hyperstimulation syndrome (OHSS) with i.v. albumin and to determine if different timing of gonadotropin coasting would affect the IVF outcomes. Design: Retrospective study. Setting: University hospital-based IVF program. Patient(s): One hundred sixty-two women undergoing IVF treatment cycles who were considered to be at high risk for developing OHSS. Intervention(s): Gonadotropin administration was withheld in 60 patients: either coasting occurred before follicular maturation (early coasting subset, n = 28) or follicular maturity was attained before coasting (late coasting subset, n = 32). Outcomes were compared in 102 patients at risk for OHSS who received i.v. albumin on the day of oocyte retrieval. Main outcome measure(s): Incidence of OHSS and outcome parameters. Result(s): Although the fertilization rates and the incidence of OHSS did not differ significantly between the coasting and i.v. albumin groups, the mean number of oocytes retrieved, the pregnancy rates, and implantation rates were significantly lower in the coasting group. There is no statistical difference in the entire outcome examined and the incidence of OHSS between the early and late coasting subsets. Conclusion(s): Coasting is as effective as i.v. albumin in preventing OHSS in high-risk patients but yields inferior pregnancy rates. Early coasting is as successful as late coasting in preventing OHSS with similar IVF outcome.

Original languageEnglish
Pages (from-to)86-90
Number of pages5
JournalFertility and Sterility
Issue number1
Publication statusPublished - Jul 1 2003
Externally publishedYes


  • Albumin
  • Coasting
  • IVF outcome
  • Ovarian hyperstimulation syndrome

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology


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