Comparison of 3 risk estimation methods for predicting cardiac outcomes in pregnant women with congenital heart disease

Chun Wei Lu; Jin Chung Shih; Ssu Yuan Chen; Hsin Hui Chiu; Jou Kou Wang; Chun An Chen; Shuenn Nan Chiu; Ming Tai Lin; Chien Nan Lee; Mei Hwan Wu

doi:10.1253/circj.CJ-14-1368

Comparison of 3 risk estimation methods for predicting cardiac outcomes in pregnant women with congenital heart disease

Chun Wei Lu, Jin Chung Shih, Ssu Yuan Chen, Hsin Hui Chiu, Jou Kou Wang, Chun An Chen, Shuenn Nan Chiu, Ming Tai Lin, Chien Nan Lee, Mei Hwan Wu

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

Background: Three risk estimation methods for predicting the cardiac outcomes of pregnancy in women with heart disease have been proposed. This study was designed to compare their prediction performance in an Asian cohort with congenital heart disease (CHD). Methods and Results: This study enrolled pregnant women with CHD who delivered their babies after the 20th gestational week between 1985 and 2011. Of 268 pregnancies in 190 women with CHD, 18 (6.7%) had cardiac complications. The incidence of maternal cardiac events among women with a CARPREG index of 0, 1 or 2 was 3.4%, 27.3% and 100%. The incidence was 2.7%, 8.6%, 11.1%, 40% and 17.6% for those with a ZAHARA score 0–0.5, 0.51–1.5, 1.51–2.5, 2.51–3.5 and >3.5. Among patients with a modified World Health Organization (WHO) classification I, II, III and IV, the incidence of maternal cardiac events was 0%, 4.0%, 12.2% and 25.7%. The c-statistic was 0.732 (95% confidence interval (CI): 0.589, 0.876; P

Original language	English
Pages (from-to)	1609-1617
Number of pages	9
Journal	Circulation Journal
Volume	79
Issue number	7
DOIs	https://doi.org/10.1253/circj.CJ-14-1368
Publication status	Published - Jun 9 2015
Externally published	Yes

Keywords

Congenital heart disease
Pregnancy
Prognosis

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1253/circj.CJ-14-1368

Cite this

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title = "Comparison of 3 risk estimation methods for predicting cardiac outcomes in pregnant women with congenital heart disease",

abstract = "Background: Three risk estimation methods for predicting the cardiac outcomes of pregnancy in women with heart disease have been proposed. This study was designed to compare their prediction performance in an Asian cohort with congenital heart disease (CHD). Methods and Results: This study enrolled pregnant women with CHD who delivered their babies after the 20th gestational week between 1985 and 2011. Of 268 pregnancies in 190 women with CHD, 18 (6.7%) had cardiac complications. The incidence of maternal cardiac events among women with a CARPREG index of 0, 1 or 2 was 3.4%, 27.3% and 100%. The incidence was 2.7%, 8.6%, 11.1%, 40% and 17.6% for those with a ZAHARA score 0–0.5, 0.51–1.5, 1.51–2.5, 2.51–3.5 and >3.5. Among patients with a modified World Health Organization (WHO) classification I, II, III and IV, the incidence of maternal cardiac events was 0%, 4.0%, 12.2% and 25.7%. The c-statistic was 0.732 (95% confidence interval (CI): 0.589, 0.876; P",

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author = "Lu, {Chun Wei} and Shih, {Jin Chung} and Chen, {Ssu Yuan} and Chiu, {Hsin Hui} and Wang, {Jou Kou} and Chen, {Chun An} and Chiu, {Shuenn Nan} and Lin, {Ming Tai} and Lee, {Chien Nan} and Wu, {Mei Hwan}",

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AU - Lu, Chun Wei

AU - Shih, Jin Chung

AU - Chen, Ssu Yuan

AU - Chiu, Hsin Hui

AU - Wang, Jou Kou

AU - Chen, Chun An

AU - Chiu, Shuenn Nan

AU - Lin, Ming Tai

AU - Lee, Chien Nan

AU - Wu, Mei Hwan

PY - 2015/6/9

Y1 - 2015/6/9

N2 - Background: Three risk estimation methods for predicting the cardiac outcomes of pregnancy in women with heart disease have been proposed. This study was designed to compare their prediction performance in an Asian cohort with congenital heart disease (CHD). Methods and Results: This study enrolled pregnant women with CHD who delivered their babies after the 20th gestational week between 1985 and 2011. Of 268 pregnancies in 190 women with CHD, 18 (6.7%) had cardiac complications. The incidence of maternal cardiac events among women with a CARPREG index of 0, 1 or 2 was 3.4%, 27.3% and 100%. The incidence was 2.7%, 8.6%, 11.1%, 40% and 17.6% for those with a ZAHARA score 0–0.5, 0.51–1.5, 1.51–2.5, 2.51–3.5 and >3.5. Among patients with a modified World Health Organization (WHO) classification I, II, III and IV, the incidence of maternal cardiac events was 0%, 4.0%, 12.2% and 25.7%. The c-statistic was 0.732 (95% confidence interval (CI): 0.589, 0.876; P

AB - Background: Three risk estimation methods for predicting the cardiac outcomes of pregnancy in women with heart disease have been proposed. This study was designed to compare their prediction performance in an Asian cohort with congenital heart disease (CHD). Methods and Results: This study enrolled pregnant women with CHD who delivered their babies after the 20th gestational week between 1985 and 2011. Of 268 pregnancies in 190 women with CHD, 18 (6.7%) had cardiac complications. The incidence of maternal cardiac events among women with a CARPREG index of 0, 1 or 2 was 3.4%, 27.3% and 100%. The incidence was 2.7%, 8.6%, 11.1%, 40% and 17.6% for those with a ZAHARA score 0–0.5, 0.51–1.5, 1.51–2.5, 2.51–3.5 and >3.5. Among patients with a modified World Health Organization (WHO) classification I, II, III and IV, the incidence of maternal cardiac events was 0%, 4.0%, 12.2% and 25.7%. The c-statistic was 0.732 (95% confidence interval (CI): 0.589, 0.876; P

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KW - Prognosis

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Comparison of 3 risk estimation methods for predicting cardiac outcomes in pregnant women with congenital heart disease

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