TY - JOUR
T1 - Comparing the efficacy of different steroids for rhinoplasty
T2 - A systematic review and network meta-analysis of randomized controlled trials
AU - Wu, Ting Ju
AU - Huang, Ya Li
AU - Kang, Yi No
AU - Chiu, Wen Kuan
AU - Chen, Jin Hua
AU - Chen, Chiehfeng
N1 - Publisher Copyright:
© 2023 British Association of Plastic, Reconstructive and Aesthetic Surgeons
PY - 2023/9
Y1 - 2023/9
N2 - Background: Rhinoplasty can cause tissue trauma and inflammatory responses. Edema and ecchymosis, especially on the face, accompanied by inflammation are common complications. The anti-inflammatory properties of steroids can reduce postoperative edema and ecchymosis. Objective: This review aims to determine the most effective type of steroids for preventing complications related to rhinoplasty. Methods: The study was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The population of comprised patients who underwent rhinoplasty or septorhinoplasty. Different types of steroids administrated intravenously during the perioperative period were compared. The primary outcome of postoperative edema and other outcomes were evaluated on postoperative day 1, 3, and 7. Random-effects model was performed. The means and standard deviations were extracted. Results: Eighteen randomized controlled trials were included. The network meta-analysis revealed that dexamethasone and methylprednisolone significantly reduced edema on postoperative day 1 compared with placebo. No significant differences between the effects of any of two types of steroids were noted. Conclusion: At least one dose of intravenous steroid intervention is recommended during the perioperative period of rhinoplasty. However, in terms of reducing edema and ecchymosis, no significant differences were noted among dexamethasone, methylprednisolone, and betamethasone.
AB - Background: Rhinoplasty can cause tissue trauma and inflammatory responses. Edema and ecchymosis, especially on the face, accompanied by inflammation are common complications. The anti-inflammatory properties of steroids can reduce postoperative edema and ecchymosis. Objective: This review aims to determine the most effective type of steroids for preventing complications related to rhinoplasty. Methods: The study was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The population of comprised patients who underwent rhinoplasty or septorhinoplasty. Different types of steroids administrated intravenously during the perioperative period were compared. The primary outcome of postoperative edema and other outcomes were evaluated on postoperative day 1, 3, and 7. Random-effects model was performed. The means and standard deviations were extracted. Results: Eighteen randomized controlled trials were included. The network meta-analysis revealed that dexamethasone and methylprednisolone significantly reduced edema on postoperative day 1 compared with placebo. No significant differences between the effects of any of two types of steroids were noted. Conclusion: At least one dose of intravenous steroid intervention is recommended during the perioperative period of rhinoplasty. However, in terms of reducing edema and ecchymosis, no significant differences were noted among dexamethasone, methylprednisolone, and betamethasone.
KW - Network meta-analysis
KW - Rhinoplasty
KW - Steroids
KW - Systematic review
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U2 - 10.1016/j.bjps.2023.04.087
DO - 10.1016/j.bjps.2023.04.087
M3 - Article
C2 - 37329745
AN - SCOPUS:85163142840
SN - 1748-6815
VL - 84
SP - 121
EP - 131
JO - Journal of Plastic, Reconstructive and Aesthetic Surgery
JF - Journal of Plastic, Reconstructive and Aesthetic Surgery
ER -