Comparative in vitro osteoinductivity study of HA and α-TCP/HA bicalcium phosphate

Yu Hao Chan; Yushan Sophie Chang; Yun-Dun Shen; Tzu Sen Yang; Shih Fu Ou; Ya Ju Hsu; Mao Suan Huang; Keng Liang Ou

doi:10.1111/ijac.12141

Comparative in vitro osteoinductivity study of HA and α-TCP/HA bicalcium phosphate

Yu Hao Chan, Yushan Sophie Chang, Yun-Dun Shen, Tzu Sen Yang, Shih Fu Ou, Ya Ju Hsu, Mao Suan Huang, Keng Liang Ou

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

A bicalcium phosphate (BCP) bioceramic comprising α-tricalcium phosphate (α-TCP) and hydroxyapatite (HA) was prepared by a two-step sintering. The microstructure of the BCP bioceramic was investigated using scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray diffraction. The in vitro osteoinductivity was evaluated by culturing MG63 osteoblast-like cells on the BCP bioceramic. Results showed that the BCP bioceramic comprising α-TCP and HA in a moderate ratio possessed a hardness of 93.7 Hv. The cells spread faster on the BCP bioceramic than those on the commercial HA. It suggested that the BCP bioceramic can enhance osteoinductivity in vivo.

Original language	English
Pages (from-to)	192-198
Number of pages	7
Journal	International Journal of Applied Ceramic Technology
Volume	12
Issue number	1
DOIs	https://doi.org/10.1111/ijac.12141
Publication status	Published - Jan 1 2015

ASJC Scopus subject areas

Condensed Matter Physics
Ceramics and Composites
Materials Chemistry
Marketing

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title = "Comparative in vitro osteoinductivity study of HA and α-TCP/HA bicalcium phosphate",

abstract = "A bicalcium phosphate (BCP) bioceramic comprising α-tricalcium phosphate (α-TCP) and hydroxyapatite (HA) was prepared by a two-step sintering. The microstructure of the BCP bioceramic was investigated using scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray diffraction. The in vitro osteoinductivity was evaluated by culturing MG63 osteoblast-like cells on the BCP bioceramic. Results showed that the BCP bioceramic comprising α-TCP and HA in a moderate ratio possessed a hardness of 93.7 Hv. The cells spread faster on the BCP bioceramic than those on the commercial HA. It suggested that the BCP bioceramic can enhance osteoinductivity in vivo.",

author = "Chan, \{Yu Hao\} and Chang, \{Yushan Sophie\} and Yun-Dun Shen and Yang, \{Tzu Sen\} and Ou, \{Shih Fu\} and Hsu, \{Ya Ju\} and Huang, \{Mao Suan\} and Ou, \{Keng Liang\}",

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doi = "10.1111/ijac.12141",

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T1 - Comparative in vitro osteoinductivity study of HA and α-TCP/HA bicalcium phosphate

AU - Chan, Yu Hao

AU - Chang, Yushan Sophie

AU - Shen, Yun-Dun

AU - Yang, Tzu Sen

AU - Ou, Shih Fu

AU - Hsu, Ya Ju

AU - Huang, Mao Suan

AU - Ou, Keng Liang

PY - 2015/1/1

Y1 - 2015/1/1

N2 - A bicalcium phosphate (BCP) bioceramic comprising α-tricalcium phosphate (α-TCP) and hydroxyapatite (HA) was prepared by a two-step sintering. The microstructure of the BCP bioceramic was investigated using scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray diffraction. The in vitro osteoinductivity was evaluated by culturing MG63 osteoblast-like cells on the BCP bioceramic. Results showed that the BCP bioceramic comprising α-TCP and HA in a moderate ratio possessed a hardness of 93.7 Hv. The cells spread faster on the BCP bioceramic than those on the commercial HA. It suggested that the BCP bioceramic can enhance osteoinductivity in vivo.

AB - A bicalcium phosphate (BCP) bioceramic comprising α-tricalcium phosphate (α-TCP) and hydroxyapatite (HA) was prepared by a two-step sintering. The microstructure of the BCP bioceramic was investigated using scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray diffraction. The in vitro osteoinductivity was evaluated by culturing MG63 osteoblast-like cells on the BCP bioceramic. Results showed that the BCP bioceramic comprising α-TCP and HA in a moderate ratio possessed a hardness of 93.7 Hv. The cells spread faster on the BCP bioceramic than those on the commercial HA. It suggested that the BCP bioceramic can enhance osteoinductivity in vivo.

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Comparative in vitro osteoinductivity study of HA and α-TCP/HA bicalcium phosphate

Abstract

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