Combination of Oncolytic Measles Virus and Ursolic Acid Synergistically Induces Oncolysis of Hepatocellular Carcinoma Cells

Ching Hsuan Liu, Chen Jei Tai, Yu Ting Kuo, Shen Shong Chang, Liang Tzung Lin

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Hepatocellular carcinoma (HCC) remains a difficult-to-treat cancer due to late diagnosis and limited curative treatment options. Developing more effective therapeutic strategies is essential for the management of HCC. Oncolytic virotherapy is a novel treatment modality for cancers, and its combination with small molecules merits further exploration. In this study, we combined oncolytic measles virus (MV) with the natural triterpenoid compound ursolic acid (UA) and evaluated their combination effect against HCC cells, including those harboring hepatitis B virus (HBV) or hepatitis C virus (HCV) replication. We found that the combination of MV and UA synergistically induced more cell death in Huh-7 HCC cells through enhanced apoptosis. In addition, increased oxidative stress and loss of mitochondrial potential were observed in the treated cells, indicating dysregulation of the mitochondria-dependent pathway. Similar synergistic cytotoxic effects were also found in HCC cells harboring HBV or HCV genomes. These findings underscore the potential of oncolytic MV and UA combination for further development as a treatment strategy for HCC.

Original languageEnglish
Article number1294
JournalViruses
Volume15
Issue number6
DOIs
Publication statusPublished - Jun 2023

Keywords

  • drug combination
  • hepatitis B virus
  • hepatitis C virus
  • hepatocellular carcinoma
  • measles virus
  • oncolytic virotherapy
  • ursolic acid

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

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