Combination of cut-log cultivated fruiting body and solid-state cultured mycelia of Taiwanofungus camphoratus ameliorates CCl4-induced liver injury in rats

Kuan Hung Lu, Yi Chun Pan, Lee Yan Sheen

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Taiwanofungus camphoratus, a medicinal mushroom indigenous to Taiwan, possesses various pharmacological functions. The most recognized ethnopharmacological relevance of T. camphoratus is hepatoprotection since it was traditionally used for treating liver disorders by Taiwan aborigines. The aim of this study is to evaluate the hepatoprotective effect of the combination of fruiting body and solid-state cultured mycelia of T. camphoratus (LDAC) on carbon tetrachloride (CCl4)-induced chronic liver damage in rats. We treated Wistar rats daily with low, medium and high [87.5, 175 and 437.5 mg/kg body weight (bw), respectively] doses of LDAC for 9 weeks. After the first week of treatment, rats were administered 20% CCl4 (0.5 mL/0.3 kg bw) twice a week to induce liver damage until the treatment ended. The results showed that administration of LDAC by oral gavage significantly reduced the absolute weight of the liver and the serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in CCl4-treated rats. The activities of the antioxidant enzymes glutathione peroxidase (GPx), glutathione reductase (GRd) and catalase (CAT) were increased by LDAC treatment. Moreover, LDAC improved CCl4-induced hepatic vacuolization, necrosis and fibrosis in a dose-dependent manner, and no adverse effects were observed in the LDAC-treated groups. Based on the results, LDAC is a promising hepatoprotective agent for preventing and ameliorating CCl4-induced chronic liver injury, and this effect might be exerted through activation of the antioxidant defense system.

Original languageEnglish
Pages (from-to)166-174
Number of pages9
JournalJournal of Traditional and Complementary Medicine
Volume10
Issue number2
DOIs
Publication statusPublished - Mar 2020
Externally publishedYes

Keywords

  • Antrodia camphorata
  • Antrodia cinnamomea
  • Carbon tetrachloride
  • Fibrosis
  • Hepatoprotection

ASJC Scopus subject areas

  • Complementary and alternative medicine

Fingerprint

Dive into the research topics of 'Combination of cut-log cultivated fruiting body and solid-state cultured mycelia of Taiwanofungus camphoratus ameliorates CCl4-induced liver injury in rats'. Together they form a unique fingerprint.

Cite this