Co-activation of primary motor cortex ipsilateral to muscles contracting in a unilateral motor task

Shin-Yi Chiou; Ray-Yau Wang; Kwong-Kum Liao; Yu-Te Wu; Chia-Feng Lu; Yea-Ru Yang

doi:10.1016/j.clinph.2013.02.001

Co-activation of primary motor cortex ipsilateral to muscles contracting in a unilateral motor task

Shin-Yi Chiou, Ray-Yau Wang, Kwong-Kum Liao, Yu-Te Wu, Chia-Feng Lu, Yea-Ru Yang

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

Objective: This study aims to investigate the role of the primary motor cortex ipsilateral to the movement (ipsilateral M1) in unilateral motor execution. Methods: Fifteen right-handed healthy subjects underwent functional magnetic resonance imaging (fMRI) and transcranial magnetic stimulation (TMS) experiments. Motor tasks were performed with the right-side limb. Subjects followed visual cues to execute movements in the scanner and independent component analysis (ICA) was applied to analyse the data. Interhemispheric inhibition (IHI), short-interval intracortical inhibition (SICI) and recruitment curves (RCs) of motor-evoked potentials (MEPs) in right M1 were measured by TMS and responses were recorded from the left flexor carpi radialis (FCR) and left anterior deltoid (AD). Results: Group ICA showed activations of bilateral M1s highly related to motor tasks. Additionally, TMS results showed significant increases of MEP RCs on the left FCR and left AD during right wrist flexion and right shoulder flexion. Prominent decreases of IHI and SICI were also observed under the same conditions. Conclusions: During unilateral muscle contraction, co-activation of the ipsilateral M1 involves additional processes modulated by intra- and interhemispheric interactions and its size of activations is specifically enhanced on the homotopic representation. Significance: The ipsilateral M1 plays a central role in unilateral motor executions. © 2013 International Federation of Clinical Neurophysiology.

Original language	English
Pages (from-to)	1353-1363
Number of pages	11
Journal	Clinical Neurophysiology
Volume	124
Issue number	7
DOIs	https://doi.org/10.1016/j.clinph.2013.02.001
Publication status	Published - 2013
Externally published	Yes

Keywords

Functional magnetic resonance imaging
Homogeneous muscle
Interhemispheric inhibition
Ipsilateral primary motor cortex co-activation
Transcranial magnetic stimulation
adult
article
evoked muscle response
female
functional magnetic resonance imaging
human
male
motor performance
movement (physiology)
normal human
primary motor cortex
priority journal
shoulder
transcranial magnetic stimulation
wrist
Adult
Analysis of Variance
Brain Mapping
Electromyography
Evoked Potentials, Motor
Female
Functional Laterality
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Motor Cortex
Movement
Muscle Contraction
Neural Inhibition
Oxygen
Principal Component Analysis
Recruitment, Neurophysiological
Transcranial Magnetic Stimulation
Young Adult

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10.1016/j.clinph.2013.02.001

Cite this

@article{a1be4a9421c745a28a55488e862ca12f,

title = "Co-activation of primary motor cortex ipsilateral to muscles contracting in a unilateral motor task",

abstract = "Objective: This study aims to investigate the role of the primary motor cortex ipsilateral to the movement (ipsilateral M1) in unilateral motor execution. Methods: Fifteen right-handed healthy subjects underwent functional magnetic resonance imaging (fMRI) and transcranial magnetic stimulation (TMS) experiments. Motor tasks were performed with the right-side limb. Subjects followed visual cues to execute movements in the scanner and independent component analysis (ICA) was applied to analyse the data. Interhemispheric inhibition (IHI), short-interval intracortical inhibition (SICI) and recruitment curves (RCs) of motor-evoked potentials (MEPs) in right M1 were measured by TMS and responses were recorded from the left flexor carpi radialis (FCR) and left anterior deltoid (AD). Results: Group ICA showed activations of bilateral M1s highly related to motor tasks. Additionally, TMS results showed significant increases of MEP RCs on the left FCR and left AD during right wrist flexion and right shoulder flexion. Prominent decreases of IHI and SICI were also observed under the same conditions. Conclusions: During unilateral muscle contraction, co-activation of the ipsilateral M1 involves additional processes modulated by intra- and interhemispheric interactions and its size of activations is specifically enhanced on the homotopic representation. Significance: The ipsilateral M1 plays a central role in unilateral motor executions. {\textcopyright} 2013 International Federation of Clinical Neurophysiology.",

keywords = "Functional magnetic resonance imaging, Homogeneous muscle, Interhemispheric inhibition, Ipsilateral primary motor cortex co-activation, Transcranial magnetic stimulation, adult, article, evoked muscle response, female, functional magnetic resonance imaging, human, male, motor performance, movement (physiology), normal human, primary motor cortex, priority journal, shoulder, transcranial magnetic stimulation, wrist, Adult, Analysis of Variance, Brain Mapping, Electromyography, Evoked Potentials, Motor, Female, Functional Laterality, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Motor Cortex, Movement, Muscle Contraction, Neural Inhibition, Oxygen, Principal Component Analysis, Recruitment, Neurophysiological, Transcranial Magnetic Stimulation, Young Adult",

author = "Shin-Yi Chiou and Ray-Yau Wang and Kwong-Kum Liao and Yu-Te Wu and Chia-Feng Lu and Yea-Ru Yang",

note = "被引用次數：8 Export Date: 31 March 2016 CODEN: CNEUF 通訊地址: Yang, Y.-R.; Department of Physical Therapy and Assistive Technology, National Yang-Ming University, 155, Sec 2, Li-Nong St., Beitou, Taipei, Taiwan; 電子郵件： [email protected] 化學物質/CAS: Oxygen, 7782-44-7 出資詳情: 98A-C-D160, Ministry of Education Aim for the Top University Plan 出資詳情: National Yang-Ming University, Taiwan 出資詳情: NSC96-2628-B-010-007-MY2, NSC, National Science Council 參考文獻: Alkadhi, H., Crelier, G.R., Boendermaker, S.H., Golay, X., Hepp-Reymond, M.C., Kollias, S.S., Reproducibility of primary motor cortex somatotopy under controlled conditions (2002) AJNR Am J Neuroradiol, 23, pp. 1524-1532; Armatas, C.A., Summers, J.J., Bradshaw, J.L., Mirror movements in normal adult subjects (1994) J Clin Exp Neuropsychol, 16, pp. 405-413; Bell, A.J., Sejnowski, T.J., An information-maximization approach to blind separation and blind deconvolution (1995) Neural Comput, 7, pp. 1129-1159; Boudrias, M.H., Goncalves, C.S., Penny, W.D., Park, C.H., Rossiter, H.E., Talelli, P., Age-related changes in causal interactions between cortical motor regions during hand grip (2012) Neuroimage, 59, pp. 3398-3405; Buccolieri, A., Abbruzzese, G., Rothwell, J.C., Relaxation from a voluntary contraction is preceded by increased excitability of motor cortical inhibitory circuits (2004) J Physiol, 558, pp. 685-695; B{\"u}tefisch, C.M., Kleiser, R., K{\"o}rber, B., M{\"u}ller, K., Wittsack, H.J., H{\"o}mberg, V., Recruitment of contralesional motor cortex in stroke patients with recovery of hand function (2005) Neurology, 64, pp. 1067-1069; Carson, R.G., Neural pathways mediating bilateral interactions between the upper limbs (2005) Brain Res Rev, 49, pp. 641-662; Chen, H., Yao, D., Zhuo, Y., Chen, L., Analysis of fMRI data by blind separation of data in a tiny spatial domain into independent temporal component (2003) Brain Topogr, 15, pp. 223-232; Chen, R., Interactions between inhibitory and excitatory circuits in the human motor cortex (2004) Exp Brain Res, 154, pp. 1-10; Chen, R., Tam, A., B{\"u}tefisch, C., Corwell, B., Ziemann, U., Rothwell, J.C., Intracortical inhibition and facilitation in different representations of the human motor cortex (1998) J Neurophysiol, 80, pp. 2870-2881; Cincota, M., Ziemann, U., Neurophysiology of unimanual motor control and mirror movements (2008) Clin Neurophysiol, 119, pp. 744-762; Daskalakis, Z.J., Christensen, B.K., Fitzgerald, P.B., Roshan, L., Chen, R., The mechanisms of interhemispheric inhibition in the human motor cortex (2002) J Physiol, 543, pp. 317-326; De Gennaro, L., Bertini, M., Pauri, F., Cristiani, R., Curcio, G., Ferrara, M., Callosal effects of transcranial magnetic stimulation (TMS): the influence of gender and stimulus parameters (2004) Neurosci Res, 48, pp. 129-137; Di Lazzaro, V., Oliviero, A., Pilato, F., Saturno, E., Dileone, M., Mazzone, P., The physiological basis of transcranial motor cortex stimulation in conscious humans (2004) Clin Neurophysiol, 115, pp. 255-266; Duque, J., Mazzocchio, R., Dambrosia, J., Murase, N., Olivier, E., Cohen, L.G., Kinematically specific interhemispheric inhibition operating in the process of generation of a voluntary movement (2005) Cereb Cortex, 15, pp. 588-593; Ferbert, A., Priori, A., Rothwell, J.C., Day, B.L., Colebatch, J.G., Marsden, C.D., Interhemispheric inhibition of the human motor cortex (1992) J Physiol, 453, pp. 525-546; Goodwill, A.M., Pearce, A.J., Kidgell, D.J., Corticomotor plasticity following unilateral strength training (2012) Muscle Nerve, 46, pp. 384-393; Hallett, M., Transcranial magnetic stimulation and the human brain (2000) Nature, 406, pp. 147-150; Hanajima, R., Ugawa, Y., Machii, K., Mochizuki, H., Terao, Y., Enomoto, H., Interhemispheric facilitation of the hand motor area in humans (2001) J Physiol, 531, pp. 849-859; Harris-Love, M.L., Perez, M.A., Chen, R., Cohen, L.G., Interhemispheric inhibition in distal and proximal arm representations in the primary motor cortex (2007) J Neurophysiol, 97, pp. 2511-2515; Hinder, M.R., Schmidt, M.W., Garry, M.I., Summers, J.J., Unilateral contractions modulate interhemispheric inhibition most strongly and most adaptively in the homologous muscle of the contralateral limb (2010) Exp Brain Res, 205, pp. 423-433; Hortob{\'a}gyi, T., Taylor, J.L., Petersen, N.T., Russell, G., Gandevia, S.C., Changes in segmental and motor cortical output with contralateral muscle contractions and altered sensory inputs in humans (2003) J Neurophysiol, 90, pp. 2451-2459; Kim, S.G., Ashe, J., Hendrich, K., Ellermann, J.M., Merkle, H., Uĝurbil, K., Functional magnetic resonance imaging of motor cortex: hemispheric asymmetry and handedness (1993) Science, 261, pp. 615-617; Kujirai, T., Caramia, M.D., Rothwell, J.C., Day, B.L., Thompson, P.D., Ferbert, A., Corticocortical inhibition in human motor cortex (1993) J Physiol, 471, pp. 501-519; Lee, M., Carroll, T.J., Cross education: possible mechanisms for the contralateral effects of unilateral resistance training (2007) Sports Med, 37, pp. 1-14; Lindenberg, R., Renga, V., Zhu, L.L., Nair, D., Schlaug, G., Bihemispheric brain stimulation facilitates motor recovery in chronic stroke patients (2010) Neurology, 75, pp. 2176-2184; McKeown, M.J., Makeig, S., Brown, G.G., Jung, T.P., Kindermann, S.S., Bell, A.J., Analysis of fMRI data by blind separation into independent spatial components (1998) Hum Brain Mapp, 6, pp. 160-188; Muellbacher, W., Facchini, S., Boroojerdi, B., Hallett, M., Changes in motor cortex excitability during ipsilateral hand muscle activation in humans (2000) Clin Neurophysiol, 111, pp. 344-349; Murase, N., Duque, J., Mazzocchio, R., Cohen, L.G., Influence of interhemispheric interactions on motor function in chronic stroke (2004) Ann Neurol, 55, pp. 400-409; Perez, M.A., Cohen, L.G., Mechanisms underlying functional changes in the primary motor cortex ipsilateral to an active hand (2008) J Neurosci, 28, pp. 5631-5640; Post, M., Bakels, R., Zijdewind, I., Inadvertent contralateral activity during a sustained unilateral contraction reflects the direction of target movement (2009) J Neurosci, 29, pp. 6353-6357; Rau, C., Plewnia, C., Hummel, F., Gerloff, C., Event-related desynchronization and excitability of the ipsilateral motor cortex during simple self-paced finger movements (2003) Clin Neurophysiol, 114, pp. 1819-1826; Rossini, P.M., Barker, A.T., Berardelli, A., Caramia, M.D., Caruso, G., Cracco, R.Q., Non-invasive electrical and magnetic stimulation of the brain, spinal cord and roots: basic principles and procedures for routine clinical application. Report of an IFCN committee (1994) Electroencephalogr Clin Neurophysiol, 91, pp. 79-92; Sanger, T.D., Garg, R.R., Chen, R., Interactions between two different inhibitory systems in the human motor cortex (2001) J Physiol, 530, pp. 307-317; Stedman, A., Davey, N.J., Ellaway, P.H., Facilitation of human first dorsal interosseous muscle responses to transcranial magnetic stimulation during voluntary contraction of the contralateral homonymous muscle (1998) Muscle Nerve, 21, pp. 1033-1039; Stinear, C.M., Walker, K.S., Byblow, W.D., Symmetric facilitation between motor cortices during contraction of ipsilateral hand muscles (2001) Exp Brain Res, 139, pp. 101-105; Stippich, C., Blatow, M., Durst, A., Dreyhaupt, J., Sartor, K., Global activation of primary motor cortex during voluntary movements in man (2007) Neuroimage, 34, pp. 1227-1237; Swinnen, S.P., Intermanual coordination: from behavioural principles to neural-network interactions (2002) Nat Rev Neurosci, 3, pp. 348-359; Swinnen, S.P., Walter, C.B., Lee, T.D., Serrien, D.J., Acquiring bimanual skills: contrasting forms of information feedback for interlimb decoupling (1993) J Exp Psychol Learn Mem Cogn, 19, pp. 1328-1344; Tazoe, T., Sakamoto, M., Nakajima, T., Endoh, T., Komiyama, T., Effects of remote muscle contraction on transcranial magnetic stimulation-induced motor evoked potentials and silent periods in humans (2007) Clin Neurophysiol, 118, pp. 1204-1212; Tinazzi, M., Zanette, G., Modulation of ipsilateral motor cortex in man during unimanual finger movements of different complexities (1998) Neurosci Lett, 244, pp. 121-124; Uematsu, A., Obata, H., Endoh, T., Kitamura, T., Hortob{\'a}gyi, T., Nakazawa, K., Asymmetrical modulation of corticospinal excitability in the contracting and resting contralateral wrist flexors during unilateral shortening, lengthening and isometric contractions (2010) Exp Brain Res, 206, pp. 59-69; Vercauteren, K., Pleysier, T., Van Belle, L., Swinnen, S.P., Wenderoth, N., Unimanual muscle activation increases interhemispheric inhibition from the active to the resting hemisphere (2008) Neurosci Lett, 445, pp. 209-213; Wenderoth, N., Puttemans, V., Vangheluwe, S., Swinnen, S.P., Bimanual training reduces spatial interference (2003) J Mot Behav, 35, pp. 296-308",

year = "2013",

doi = "10.1016/j.clinph.2013.02.001",

language = "English",

volume = "124",

pages = "1353--1363",

journal = "Clinical Neurophysiology",

issn = "1388-2457",

publisher = "Elsevier Ireland Ltd",

number = "7",

}

TY - JOUR

T1 - Co-activation of primary motor cortex ipsilateral to muscles contracting in a unilateral motor task

AU - Chiou, Shin-Yi

AU - Wang, Ray-Yau

AU - Liao, Kwong-Kum

AU - Wu, Yu-Te

AU - Lu, Chia-Feng

AU - Yang, Yea-Ru

N1 - 被引用次數：8 Export Date: 31 March 2016 CODEN: CNEUF 通訊地址: Yang, Y.-R.; Department of Physical Therapy and Assistive Technology, National Yang-Ming University, 155, Sec 2, Li-Nong St., Beitou, Taipei, Taiwan; 電子郵件： [email protected] 化學物質/CAS: Oxygen, 7782-44-7 出資詳情: 98A-C-D160, Ministry of Education Aim for the Top University Plan 出資詳情: National Yang-Ming University, Taiwan 出資詳情: NSC96-2628-B-010-007-MY2, NSC, National Science Council 參考文獻: Alkadhi, H., Crelier, G.R., Boendermaker, S.H., Golay, X., Hepp-Reymond, M.C., Kollias, S.S., Reproducibility of primary motor cortex somatotopy under controlled conditions (2002) AJNR Am J Neuroradiol, 23, pp. 1524-1532; Armatas, C.A., Summers, J.J., Bradshaw, J.L., Mirror movements in normal adult subjects (1994) J Clin Exp Neuropsychol, 16, pp. 405-413; Bell, A.J., Sejnowski, T.J., An information-maximization approach to blind separation and blind deconvolution (1995) Neural Comput, 7, pp. 1129-1159; Boudrias, M.H., Goncalves, C.S., Penny, W.D., Park, C.H., Rossiter, H.E., Talelli, P., Age-related changes in causal interactions between cortical motor regions during hand grip (2012) Neuroimage, 59, pp. 3398-3405; Buccolieri, A., Abbruzzese, G., Rothwell, J.C., Relaxation from a voluntary contraction is preceded by increased excitability of motor cortical inhibitory circuits (2004) J Physiol, 558, pp. 685-695; Bütefisch, C.M., Kleiser, R., Körber, B., Müller, K., Wittsack, H.J., Hömberg, V., Recruitment of contralesional motor cortex in stroke patients with recovery of hand function (2005) Neurology, 64, pp. 1067-1069; Carson, R.G., Neural pathways mediating bilateral interactions between the upper limbs (2005) Brain Res Rev, 49, pp. 641-662; Chen, H., Yao, D., Zhuo, Y., Chen, L., Analysis of fMRI data by blind separation of data in a tiny spatial domain into independent temporal component (2003) Brain Topogr, 15, pp. 223-232; Chen, R., Interactions between inhibitory and excitatory circuits in the human motor cortex (2004) Exp Brain Res, 154, pp. 1-10; Chen, R., Tam, A., Bütefisch, C., Corwell, B., Ziemann, U., Rothwell, J.C., Intracortical inhibition and facilitation in different representations of the human motor cortex (1998) J Neurophysiol, 80, pp. 2870-2881; Cincota, M., Ziemann, U., Neurophysiology of unimanual motor control and mirror movements (2008) Clin Neurophysiol, 119, pp. 744-762; Daskalakis, Z.J., Christensen, B.K., Fitzgerald, P.B., Roshan, L., Chen, R., The mechanisms of interhemispheric inhibition in the human motor cortex (2002) J Physiol, 543, pp. 317-326; De Gennaro, L., Bertini, M., Pauri, F., Cristiani, R., Curcio, G., Ferrara, M., Callosal effects of transcranial magnetic stimulation (TMS): the influence of gender and stimulus parameters (2004) Neurosci Res, 48, pp. 129-137; Di Lazzaro, V., Oliviero, A., Pilato, F., Saturno, E., Dileone, M., Mazzone, P., The physiological basis of transcranial motor cortex stimulation in conscious humans (2004) Clin Neurophysiol, 115, pp. 255-266; Duque, J., Mazzocchio, R., Dambrosia, J., Murase, N., Olivier, E., Cohen, L.G., Kinematically specific interhemispheric inhibition operating in the process of generation of a voluntary movement (2005) Cereb Cortex, 15, pp. 588-593; Ferbert, A., Priori, A., Rothwell, J.C., Day, B.L., Colebatch, J.G., Marsden, C.D., Interhemispheric inhibition of the human motor cortex (1992) J Physiol, 453, pp. 525-546; Goodwill, A.M., Pearce, A.J., Kidgell, D.J., Corticomotor plasticity following unilateral strength training (2012) Muscle Nerve, 46, pp. 384-393; Hallett, M., Transcranial magnetic stimulation and the human brain (2000) Nature, 406, pp. 147-150; Hanajima, R., Ugawa, Y., Machii, K., Mochizuki, H., Terao, Y., Enomoto, H., Interhemispheric facilitation of the hand motor area in humans (2001) J Physiol, 531, pp. 849-859; Harris-Love, M.L., Perez, M.A., Chen, R., Cohen, L.G., Interhemispheric inhibition in distal and proximal arm representations in the primary motor cortex (2007) J Neurophysiol, 97, pp. 2511-2515; Hinder, M.R., Schmidt, M.W., Garry, M.I., Summers, J.J., Unilateral contractions modulate interhemispheric inhibition most strongly and most adaptively in the homologous muscle of the contralateral limb (2010) Exp Brain Res, 205, pp. 423-433; Hortobágyi, T., Taylor, J.L., Petersen, N.T., Russell, G., Gandevia, S.C., Changes in segmental and motor cortical output with contralateral muscle contractions and altered sensory inputs in humans (2003) J Neurophysiol, 90, pp. 2451-2459; Kim, S.G., Ashe, J., Hendrich, K., Ellermann, J.M., Merkle, H., Uĝurbil, K., Functional magnetic resonance imaging of motor cortex: hemispheric asymmetry and handedness (1993) Science, 261, pp. 615-617; Kujirai, T., Caramia, M.D., Rothwell, J.C., Day, B.L., Thompson, P.D., Ferbert, A., Corticocortical inhibition in human motor cortex (1993) J Physiol, 471, pp. 501-519; Lee, M., Carroll, T.J., Cross education: possible mechanisms for the contralateral effects of unilateral resistance training (2007) Sports Med, 37, pp. 1-14; Lindenberg, R., Renga, V., Zhu, L.L., Nair, D., Schlaug, G., Bihemispheric brain stimulation facilitates motor recovery in chronic stroke patients (2010) Neurology, 75, pp. 2176-2184; McKeown, M.J., Makeig, S., Brown, G.G., Jung, T.P., Kindermann, S.S., Bell, A.J., Analysis of fMRI data by blind separation into independent spatial components (1998) Hum Brain Mapp, 6, pp. 160-188; Muellbacher, W., Facchini, S., Boroojerdi, B., Hallett, M., Changes in motor cortex excitability during ipsilateral hand muscle activation in humans (2000) Clin Neurophysiol, 111, pp. 344-349; Murase, N., Duque, J., Mazzocchio, R., Cohen, L.G., Influence of interhemispheric interactions on motor function in chronic stroke (2004) Ann Neurol, 55, pp. 400-409; Perez, M.A., Cohen, L.G., Mechanisms underlying functional changes in the primary motor cortex ipsilateral to an active hand (2008) J Neurosci, 28, pp. 5631-5640; Post, M., Bakels, R., Zijdewind, I., Inadvertent contralateral activity during a sustained unilateral contraction reflects the direction of target movement (2009) J Neurosci, 29, pp. 6353-6357; Rau, C., Plewnia, C., Hummel, F., Gerloff, C., Event-related desynchronization and excitability of the ipsilateral motor cortex during simple self-paced finger movements (2003) Clin Neurophysiol, 114, pp. 1819-1826; Rossini, P.M., Barker, A.T., Berardelli, A., Caramia, M.D., Caruso, G., Cracco, R.Q., Non-invasive electrical and magnetic stimulation of the brain, spinal cord and roots: basic principles and procedures for routine clinical application. Report of an IFCN committee (1994) Electroencephalogr Clin Neurophysiol, 91, pp. 79-92; Sanger, T.D., Garg, R.R., Chen, R., Interactions between two different inhibitory systems in the human motor cortex (2001) J Physiol, 530, pp. 307-317; Stedman, A., Davey, N.J., Ellaway, P.H., Facilitation of human first dorsal interosseous muscle responses to transcranial magnetic stimulation during voluntary contraction of the contralateral homonymous muscle (1998) Muscle Nerve, 21, pp. 1033-1039; Stinear, C.M., Walker, K.S., Byblow, W.D., Symmetric facilitation between motor cortices during contraction of ipsilateral hand muscles (2001) Exp Brain Res, 139, pp. 101-105; Stippich, C., Blatow, M., Durst, A., Dreyhaupt, J., Sartor, K., Global activation of primary motor cortex during voluntary movements in man (2007) Neuroimage, 34, pp. 1227-1237; Swinnen, S.P., Intermanual coordination: from behavioural principles to neural-network interactions (2002) Nat Rev Neurosci, 3, pp. 348-359; Swinnen, S.P., Walter, C.B., Lee, T.D., Serrien, D.J., Acquiring bimanual skills: contrasting forms of information feedback for interlimb decoupling (1993) J Exp Psychol Learn Mem Cogn, 19, pp. 1328-1344; Tazoe, T., Sakamoto, M., Nakajima, T., Endoh, T., Komiyama, T., Effects of remote muscle contraction on transcranial magnetic stimulation-induced motor evoked potentials and silent periods in humans (2007) Clin Neurophysiol, 118, pp. 1204-1212; Tinazzi, M., Zanette, G., Modulation of ipsilateral motor cortex in man during unimanual finger movements of different complexities (1998) Neurosci Lett, 244, pp. 121-124; Uematsu, A., Obata, H., Endoh, T., Kitamura, T., Hortobágyi, T., Nakazawa, K., Asymmetrical modulation of corticospinal excitability in the contracting and resting contralateral wrist flexors during unilateral shortening, lengthening and isometric contractions (2010) Exp Brain Res, 206, pp. 59-69; Vercauteren, K., Pleysier, T., Van Belle, L., Swinnen, S.P., Wenderoth, N., Unimanual muscle activation increases interhemispheric inhibition from the active to the resting hemisphere (2008) Neurosci Lett, 445, pp. 209-213; Wenderoth, N., Puttemans, V., Vangheluwe, S., Swinnen, S.P., Bimanual training reduces spatial interference (2003) J Mot Behav, 35, pp. 296-308

PY - 2013

Y1 - 2013

N2 - Objective: This study aims to investigate the role of the primary motor cortex ipsilateral to the movement (ipsilateral M1) in unilateral motor execution. Methods: Fifteen right-handed healthy subjects underwent functional magnetic resonance imaging (fMRI) and transcranial magnetic stimulation (TMS) experiments. Motor tasks were performed with the right-side limb. Subjects followed visual cues to execute movements in the scanner and independent component analysis (ICA) was applied to analyse the data. Interhemispheric inhibition (IHI), short-interval intracortical inhibition (SICI) and recruitment curves (RCs) of motor-evoked potentials (MEPs) in right M1 were measured by TMS and responses were recorded from the left flexor carpi radialis (FCR) and left anterior deltoid (AD). Results: Group ICA showed activations of bilateral M1s highly related to motor tasks. Additionally, TMS results showed significant increases of MEP RCs on the left FCR and left AD during right wrist flexion and right shoulder flexion. Prominent decreases of IHI and SICI were also observed under the same conditions. Conclusions: During unilateral muscle contraction, co-activation of the ipsilateral M1 involves additional processes modulated by intra- and interhemispheric interactions and its size of activations is specifically enhanced on the homotopic representation. Significance: The ipsilateral M1 plays a central role in unilateral motor executions. © 2013 International Federation of Clinical Neurophysiology.

AB - Objective: This study aims to investigate the role of the primary motor cortex ipsilateral to the movement (ipsilateral M1) in unilateral motor execution. Methods: Fifteen right-handed healthy subjects underwent functional magnetic resonance imaging (fMRI) and transcranial magnetic stimulation (TMS) experiments. Motor tasks were performed with the right-side limb. Subjects followed visual cues to execute movements in the scanner and independent component analysis (ICA) was applied to analyse the data. Interhemispheric inhibition (IHI), short-interval intracortical inhibition (SICI) and recruitment curves (RCs) of motor-evoked potentials (MEPs) in right M1 were measured by TMS and responses were recorded from the left flexor carpi radialis (FCR) and left anterior deltoid (AD). Results: Group ICA showed activations of bilateral M1s highly related to motor tasks. Additionally, TMS results showed significant increases of MEP RCs on the left FCR and left AD during right wrist flexion and right shoulder flexion. Prominent decreases of IHI and SICI were also observed under the same conditions. Conclusions: During unilateral muscle contraction, co-activation of the ipsilateral M1 involves additional processes modulated by intra- and interhemispheric interactions and its size of activations is specifically enhanced on the homotopic representation. Significance: The ipsilateral M1 plays a central role in unilateral motor executions. © 2013 International Federation of Clinical Neurophysiology.

KW - Functional magnetic resonance imaging

KW - Homogeneous muscle

KW - Interhemispheric inhibition

KW - Ipsilateral primary motor cortex co-activation

KW - Transcranial magnetic stimulation

KW - adult

KW - article

KW - evoked muscle response

KW - female

KW - functional magnetic resonance imaging

KW - human

KW - male

KW - motor performance

KW - movement (physiology)

KW - normal human

KW - primary motor cortex

KW - priority journal

KW - shoulder

KW - transcranial magnetic stimulation

KW - wrist

KW - Adult

KW - Analysis of Variance

KW - Brain Mapping

KW - Electromyography

KW - Evoked Potentials, Motor

KW - Female

KW - Functional Laterality

KW - Humans

KW - Image Processing, Computer-Assisted

KW - Magnetic Resonance Imaging

KW - Male

KW - Motor Cortex

KW - Movement

KW - Muscle Contraction

KW - Neural Inhibition

KW - Oxygen

KW - Principal Component Analysis

KW - Recruitment, Neurophysiological

KW - Transcranial Magnetic Stimulation

KW - Young Adult

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DO - 10.1016/j.clinph.2013.02.001

M3 - Article

SN - 1388-2457

VL - 124

SP - 1353

EP - 1363

JO - Clinical Neurophysiology

JF - Clinical Neurophysiology

IS - 7

ER -

Co-activation of primary motor cortex ipsilateral to muscles contracting in a unilateral motor task

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