TY - JOUR
T1 - Clustering of unconventional cardiovascular risk factors among taiwanese hemodialysis patients
AU - Hung, Shih Yuan
AU - Liou, Hung Hsiang
AU - Ger, Luo Ping
AU - Chen, Liang Ken
AU - Liu, Mei Chyn
AU - Chung, Hsiao Min
AU - Chou, Kang Ju
AU - Chen, Tso Hsiao
AU - Lin, Chih Kuang
AU - Yang, Yu
PY - 2009/9
Y1 - 2009/9
N2 - Background: Cardiovascular disease (CAVD) is the most common cause of mortality for chronic hemodialysis (HD) patients, yet the risk factors for the events have not been well established. Methods: We conducted a multicenter cross-sectional survey in 995 chronic HD patients recruited from 12 HD centers in Taiwan to investigate the prevalence of CAVD, including coronary heart disease (CHD), cerebrovascular disease (CVD), and peripheral vascular disease (PVD), and related them to 30 different parameters. Results: The mean age of 995 patients (499 males/496 females) was 56.4 ± 12.3 years, and average HD duration was 59.8 ± 51.2 months. The prevalence rates of CHD, CVD, and PVD were 24.0, 6.0, and 5.3%, respectively. Results of our multivariate logistic regression analysis showed that out of the conventional CAVD risk factors, only old age and diabetes could be significantly associated with CAVD. Meanwhile, we found some novel clinical correlates, including low apolipoprotein A-I and creatinine for CHD, low uric acid for CVD, and low hematocrit and low diastolic blood pressure for PVD. Interestingly, left ventricular hypertrophy was found to be an independent correlate for all three: CHD, CVD, and PVD. Conclusions: Our study suggests that consideration of conventional cardiovascular risk factors as well as unconventional risk factors might better assess the risk for CAVD among HD patients.
AB - Background: Cardiovascular disease (CAVD) is the most common cause of mortality for chronic hemodialysis (HD) patients, yet the risk factors for the events have not been well established. Methods: We conducted a multicenter cross-sectional survey in 995 chronic HD patients recruited from 12 HD centers in Taiwan to investigate the prevalence of CAVD, including coronary heart disease (CHD), cerebrovascular disease (CVD), and peripheral vascular disease (PVD), and related them to 30 different parameters. Results: The mean age of 995 patients (499 males/496 females) was 56.4 ± 12.3 years, and average HD duration was 59.8 ± 51.2 months. The prevalence rates of CHD, CVD, and PVD were 24.0, 6.0, and 5.3%, respectively. Results of our multivariate logistic regression analysis showed that out of the conventional CAVD risk factors, only old age and diabetes could be significantly associated with CAVD. Meanwhile, we found some novel clinical correlates, including low apolipoprotein A-I and creatinine for CHD, low uric acid for CVD, and low hematocrit and low diastolic blood pressure for PVD. Interestingly, left ventricular hypertrophy was found to be an independent correlate for all three: CHD, CVD, and PVD. Conclusions: Our study suggests that consideration of conventional cardiovascular risk factors as well as unconventional risk factors might better assess the risk for CAVD among HD patients.
KW - Cardiovascular disease
KW - Cardiovascular risk factors
KW - Cerebrovascular disease
KW - Coronary heart disease
KW - Hemodialysis
KW - Peripheral vascular disease
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U2 - 10.1159/000218105
DO - 10.1159/000218105
M3 - Article
C2 - 19420907
AN - SCOPUS:65449119981
SN - 0250-8095
VL - 30
SP - 222
EP - 231
JO - American Journal of Nephrology
JF - American Journal of Nephrology
IS - 3
ER -
