Clinicopathologic factors related to metastasis in retinoblastoma

An Guor Wang, Wen-Ming Hsu, Wei Wei Hsia, Jorn Hon Liu, May Yung Yen

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Purpose: To investigate the orbital invasion and metastatic pattern in retinoblastoma, and to analyze the correlation with other pathologic and prognostic factors. Methods: Pathologic and admission records of 45 patients with a pathologically confirmed diagnosis of retinoblastoma during the past 20 years were reviewed. Clinical risk factors and pathologic findings were analyzed for association with tumor invasion/metastasis using chi-square, Fisher's exact, and Student's t tests. Results: Clinical risk factors such as exophthalmos, cataract, and pseudohypopyon were significantly correlated with tumor invasion/metastasis. The pathologic finding of choroid involvement was highly predictive of tumor invasion/metastasis. Delayed enucleation (>3 months) also was significantly correlated with tumor invasion/metastasis. Conclusion: Tumor invasion/metastasis is strongly associated with various ocular, pathologic, and treatment outcome factors. Identification of these risk factors may help plan treatment regimens.

Original languageEnglish
Pages (from-to)166-171
Number of pages6
JournalJournal of Pediatric Ophthalmology and Strabismus
Issue number3
Publication statusPublished - May 1 2001
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Ophthalmology


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