Clinical manifestations of Kikuchi's disease in southern Taiwan

Hsin Liang Yu, Susan Shin Jung Lee, Hung Chin Tsai, Chun Kai Huang, Yao Shen Chen, Hsi Hsin Lin, Shue Ren Wann, Yung Ching Liu, Hui Hwa Tseng

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)


Histiocytic necrotizing lymphadenitis, or Kikuchi's disease (KD), is a self-limiting cervical lymphadenitis of unknown origin. The diagnosis of KD is problematic due to the lack of specific laboratory tests. This study reviewed the clinical characteristics of 58 patients with KD. Clinical manifestations were of considerable diversity. The mean age of patients was 24.88 ± 7.44 years and there was a female predominance (1.76:1). The most frequent clinical findings were enlarged tender lymph nodes (50%), fever (43%), sore throat (21%), non-productive cough (12%), headache (10%), chills (9%) and rhinorrhea (9%). The most common initial laboratory abnormalities were leukopenia (29%), elevated erythrocyte sedimentation rate (14%), liver function impairment (14%), elevated C-reactive protein level (12%), and anemia (10%). Most patients had unilateral lymph node involvement (79%), which was usually located in the posterior triangle of the cervical lymph nodes (90%). Most patients had no comorbid disease (93%). No recurrence occurred. KD should be included in the differential diagnosis of fever with cervical lymphadenopathy.

Original languageEnglish
Pages (from-to)35-40
Number of pages6
JournalJournal of Microbiology, Immunology and Infection
Issue number1
Publication statusPublished - Feb 2005
Externally publishedYes


  • Apoptosis
  • Differential diagnosis
  • Histiocytic necrotizing lymphadenitis
  • Kikuchi's disease
  • Signs and symptoms

ASJC Scopus subject areas

  • Microbiology (medical)
  • Immunology and Allergy
  • Immunology and Microbiology(all)


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