TY - JOUR
T1 - Clinical Manifestations and Risk Factors Influencing Eradication of Extensive Multidrug-resistant Acinetobacter baumannii from the Respiratory Tract
AU - Hsieh, Tai Chin
AU - Jean, ShioShin
AU - Chen, Fu-Lun
AU - Ou, Tsong Yih
AU - Wang, Giueng-Chueng
AU - Lee, Wen-Sen
PY - 2014/12/1
Y1 - 2014/12/1
N2 - Purpose: Extensive multidrug-resistant Acinetobacter baumannii (XDRAB) has increasingly emerged as one of the most difficult bacteria to treat in the healthcare setting. In this study, we intended to evaluate the factors affecting eradicating XDRAB from the respiratory tract, clinical manifestations, and treatment outcomes. Methods: We retrospectively reviewed the medical records of patients who had XDRAB isolated from the respiratory tract in our medical center from January 1, 2012 to February 28, 2013. Results: In total, 87 patients were included in this study. Eradication was achieved in 69 patients (79.3%). The factors that negatively affect eradication of XDRAB by aerosolized colistin therapy for two weeks included: (1) receiving noninvasive mechanical ventilation; (2) being infected/colonized during residency in long-term care facilities; and (3) receiving combination therapy with intravenous tigecycline. The 30-day mortality in patients with versus without eradication was 26.1% versus 55.6%, respectively (. p
AB - Purpose: Extensive multidrug-resistant Acinetobacter baumannii (XDRAB) has increasingly emerged as one of the most difficult bacteria to treat in the healthcare setting. In this study, we intended to evaluate the factors affecting eradicating XDRAB from the respiratory tract, clinical manifestations, and treatment outcomes. Methods: We retrospectively reviewed the medical records of patients who had XDRAB isolated from the respiratory tract in our medical center from January 1, 2012 to February 28, 2013. Results: In total, 87 patients were included in this study. Eradication was achieved in 69 patients (79.3%). The factors that negatively affect eradication of XDRAB by aerosolized colistin therapy for two weeks included: (1) receiving noninvasive mechanical ventilation; (2) being infected/colonized during residency in long-term care facilities; and (3) receiving combination therapy with intravenous tigecycline. The 30-day mortality in patients with versus without eradication was 26.1% versus 55.6%, respectively (. p
KW - Colistin
KW - Nosocomial infection
KW - Pneumonia
KW - Tigecycline
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U2 - 10.1016/j.jecm.2014.10.003
DO - 10.1016/j.jecm.2014.10.003
M3 - Article
AN - SCOPUS:84916200536
SN - 1878-3317
VL - 6
SP - 213
EP - 216
JO - Journal of Experimental and Clinical Medicine
JF - Journal of Experimental and Clinical Medicine
IS - 6
ER -