Clinical burden of autosomal dominant polycystic kidney disease

Peir Haur Hung, Chien Hung Lin, Kuan Yu Hung, Chih Hsin Muo, Mu Chi Chung, Chao Hsiang Chang, Chi Jung Chung

Research output: Contribution to journalArticlepeer-review

Abstract

There are no specific therapies for autosomal dominant polycystic kidney disease (ADPKD), and clinical data evaluating the effects of non-specific therapies on ADPKD patients are scarce. We therefore evaluated those effects using data from a longitudinal health insurance database collected from 2000-2010. We individually selected patients with and without ADPKD from inpatient data files as well as from the catastrophic illness registry in Taiwan based on 1:5 frequency matching for sex, age, and index year. The hazard ratios (HR) of all-cause mortality, ischemic stroke, hemorrhagic stroke and end-stage renal disease (ESRD) in ADPKD inpatients were elevated as compared to the controls. Similarly, ADPKD patients from the catastrophic illness registry had an increased risk of hemorrhagic stroke and ESRD. Allopurinol users also had an increased risk of all-cause mortality. The HR for developing ESRD after medication exposure was 0.47-fold for statin and 1.93-fold for pentoxifylline. These results reveal that patients with ADPKD (either inpatient or from the catastrophic illness registry) are at elevated risk for hemorrhagic stroke and ESRD, and suggest that allopurinol and pentoxifylline should not be prescribed to ADPKD patients due to possible adverse effects.

Original languageEnglish
Pages (from-to)3899-3910
Number of pages12
JournalAging
Volume12
Issue number4
DOIs
Publication statusPublished - Feb 29 2020
Externally publishedYes

Keywords

  • All-cause mortality
  • Autosomal dominant polycystic kidney disease
  • End-stage renal disease
  • Hemorrhagic stroke
  • Time-dependent cox proportional hazard regression

ASJC Scopus subject areas

  • Ageing
  • Cell Biology

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