TY - JOUR
T1 - Clerodendrum inerme leaf extract alleviates animal behaviors, hyperlocomotion, and prepulse inhibition disruptions, mimicking tourette syndrome and schizophrenia
AU - Chen, Hon Lie
AU - Lee, Hsin Jung
AU - Huang, Wei Jan
AU - Chou, Jui Feng
AU - Fan, Pi Chuan
AU - Du, Jung Chieh
AU - Ku, Yuan Ling
AU - Chiou, Lih Chu
PY - 2012
Y1 - 2012
N2 - Previously, we found a patient with intractable motor tic disorder, a spectrum of Tourette syndrome (TS), responsive to the ground leaf juice of Clerodendrum inerme (CI). Here, we examined the effect of the ethanol extract of CI leaves (CI extract) on animal behaviors mimicking TS, hyperlocomotion, and sensorimotor gating deficit. The latter is also observed in schizophrenic patients and can be reflected by a disruption of prepulse inhibition of acoustic startle response (PPI) in animal models induced by methamphetamine and NMDA channel blockers (ketamine or MK-801), based on hyperdopaminergic and hypoglutamatergic hypotheses, respectively. CI extract (10-300mg/kg, i.p.) dose-dependently inhibited hyperlocomotion induced by methamphetamine (2mg/kg, i.p.) and PPI disruptions induced by methamphetamine, ketamine (30mg/kg, i.p.), and MK-801 (0.3mg/kg, i.p.) but did not affect spontaneous locomotor activity, rotarod performance, and grip force. These results suggest that CI extract can relieve hyperlocomotion and improve sensorimotor gating deficit, supporting the therapeutic potential of CI for TS and schizophrenia.
AB - Previously, we found a patient with intractable motor tic disorder, a spectrum of Tourette syndrome (TS), responsive to the ground leaf juice of Clerodendrum inerme (CI). Here, we examined the effect of the ethanol extract of CI leaves (CI extract) on animal behaviors mimicking TS, hyperlocomotion, and sensorimotor gating deficit. The latter is also observed in schizophrenic patients and can be reflected by a disruption of prepulse inhibition of acoustic startle response (PPI) in animal models induced by methamphetamine and NMDA channel blockers (ketamine or MK-801), based on hyperdopaminergic and hypoglutamatergic hypotheses, respectively. CI extract (10-300mg/kg, i.p.) dose-dependently inhibited hyperlocomotion induced by methamphetamine (2mg/kg, i.p.) and PPI disruptions induced by methamphetamine, ketamine (30mg/kg, i.p.), and MK-801 (0.3mg/kg, i.p.) but did not affect spontaneous locomotor activity, rotarod performance, and grip force. These results suggest that CI extract can relieve hyperlocomotion and improve sensorimotor gating deficit, supporting the therapeutic potential of CI for TS and schizophrenia.
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U2 - 10.1155/2012/284301
DO - 10.1155/2012/284301
M3 - Article
C2 - 22844330
AN - SCOPUS:84864952440
SN - 1741-427X
VL - 2012
JO - Evidence-based Complementary and Alternative Medicine
JF - Evidence-based Complementary and Alternative Medicine
M1 - 284301
ER -