CKD Care Programs and Incident Kidney Failure: A Study of a National Disease Management Program in Taiwan

Ming Yen Lin, Yi Wen Chiu, Yung Ho Hsu, Mai Szu Wu, Jer Ming Chang, Chih Cheng Hsu, Chih Wei Yang, Wu Chang Yang, Shang Jyh Hwang

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Rationale & Objective: Taiwan implemented national pay-for-performance programs for chronic kidney disease (CKD) care in 2006 and 2011; however, it is unknown whether this affected trends in maintenance dialysis. This study assessed the temporal trends in the incidence, prevalence, and mortality of individuals treated with maintenance dialysis from 2002-2016 in Taiwan. Study Design: Follow-up study using Taiwan Renal Disease System Databases. Setting & Participants: Participants who received dialysis for ≥90 days. Predictors: Age, sex, and calendar year. Outcomes: Incidence, prevalence of maintenance dialysis, or death, ascertained using the National Death Registry database. Analytical Approach: The estimated annual percentage change was assessed by a generalized linear model, and the association of the programs with changes in the incidence of maintenance dialysis was evaluated using an age-period-cohort model. Results: A total of 144,258 incident cases with a follow-up of 346 million person-years were analyzed during the observed periods. The estimated annual percentage change of the expected crude incidence rate was slightly reduced by 0.41% (95% CI, −1.06 to 0.24) and was more obvious in women and patients aged greater than 70 years; whereas, it was significantly increased in those aged greater than 75 years. After disentangling age and cohort effects, the implementation of the care programs was associated with an overall net drift of −1.09% (95% CI, −1.65 to −0.52) per year and a significant linear reduction in the period rate ratio from 1.06 (95% CI, 1.02-1.09) in the years 2002-2006 to 0.95 (95% CI, 0.92-0.98) in 2012-2016, using years 2007-2011 as reference. Limitations: The findings of the study may have limited inferences to other countries with different health care systems. Conclusions: The implementation of universal CKD care programs in Taiwan has significantly reduced the long-term trends in the incidence of maintenance dialysis; hence, devoting governmental resources to CKD care and prevention is advocated.

Original languageEnglish
Article number100485
JournalKidney Medicine
Issue number7
Publication statusPublished - Jul 2022


  • Chronic kidney disease care
  • dialysis duration
  • end-stage kidney disease
  • incidence
  • kidney failure
  • maintenance dialysis
  • mortality
  • prevalence
  • secular trends
  • universal care

ASJC Scopus subject areas

  • Internal Medicine
  • Nephrology


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