TY - JOUR
T1 - Circulating tissue inhibitor of matrix metalloproteinase-1 is associated with aldosterone-induced diastolic dysfunction
AU - Hung, Chi Sheng
AU - Chou, Chia Hung
AU - Wu, Xue Ming
AU - Chang, Yi Yao
AU - Wu, Vin Cent
AU - Chen, Ying Hsien
AU - Chang, Yuan Shian
AU - Tsai, Yao Chou
AU - Su, Ming Jai
AU - Ho, Yi Lwun
AU - Chen, Ming Fong
AU - Wu, Kwan Dun
AU - Lin, Yen Hung
PY - 2015
Y1 - 2015
N2 - Objective: To test if collagen markers are associated with aldosterone-induced diastolic dysfunction. Background: Although primary aldosteronism is associated with more prominent cardiac remodeling and diastolic dysfunction, the reversibility of diastolic function is unclear. In addition, there is no known biomarker associated with aldosterone-induced diastolic dysfunction. Methods: We enrolled 27 patients with aldosteroneproducing adenoma (APA) preparing for adrenalectomy, and 27 patients with essential hypertension prospectively from October 2006 to March 2010 at a tertiary referral center. Plasma matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) were measured, and echocardiography including tissue Doppler images was performed in both groups and 1 year after receiving adrenalectomy in the APA group. Results: The baseline plasma TIMP-1 level (88.4±38.7 vs. 63.6±32.5 ng/ml; P=0.014), left ventricular mass index (LVMI), and E/E' ratio (11.5±2.9 vs. 9.0±2.1; P<0.001) were significantly higher in the APA group. The baseline plasma TIMP-1 level significantly correlated with the E/E' ratio, LVMI, interventricular septum, and left atrial diameter. The plasma MMP-2 level did not correlate with the left ventricular structure parameters, except for interventricular septum thickness. After adrenalectomy, LVMI and E/E' ratio improved significantly. The postadrenalectomy plasma TIMP-1 levels, but not MMP-2 levels, also decreased. The change of plasma TIMP-1 levels was negatively associated with the postadrenalectomy E/E' ratio after adjustment for age, sex, BMI, and mean blood pressure (β-coefficient=-3.6, P=0.004). Conclusion: Excess of aldosterone induces cardiac diastolic dysfunction, which is reversible by adrenalectomy. TIMP-1 is associated with the aldosterone-induced diastolic dysfunction.
AB - Objective: To test if collagen markers are associated with aldosterone-induced diastolic dysfunction. Background: Although primary aldosteronism is associated with more prominent cardiac remodeling and diastolic dysfunction, the reversibility of diastolic function is unclear. In addition, there is no known biomarker associated with aldosterone-induced diastolic dysfunction. Methods: We enrolled 27 patients with aldosteroneproducing adenoma (APA) preparing for adrenalectomy, and 27 patients with essential hypertension prospectively from October 2006 to March 2010 at a tertiary referral center. Plasma matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) were measured, and echocardiography including tissue Doppler images was performed in both groups and 1 year after receiving adrenalectomy in the APA group. Results: The baseline plasma TIMP-1 level (88.4±38.7 vs. 63.6±32.5 ng/ml; P=0.014), left ventricular mass index (LVMI), and E/E' ratio (11.5±2.9 vs. 9.0±2.1; P<0.001) were significantly higher in the APA group. The baseline plasma TIMP-1 level significantly correlated with the E/E' ratio, LVMI, interventricular septum, and left atrial diameter. The plasma MMP-2 level did not correlate with the left ventricular structure parameters, except for interventricular septum thickness. After adrenalectomy, LVMI and E/E' ratio improved significantly. The postadrenalectomy plasma TIMP-1 levels, but not MMP-2 levels, also decreased. The change of plasma TIMP-1 levels was negatively associated with the postadrenalectomy E/E' ratio after adjustment for age, sex, BMI, and mean blood pressure (β-coefficient=-3.6, P=0.004). Conclusion: Excess of aldosterone induces cardiac diastolic dysfunction, which is reversible by adrenalectomy. TIMP-1 is associated with the aldosterone-induced diastolic dysfunction.
KW - Diastolic function
KW - Left ventricular hypertrophy
KW - Primary aldosteronism
KW - TIMP-1
UR - http://www.scopus.com/inward/record.url?scp=84942609499&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84942609499&partnerID=8YFLogxK
U2 - 10.1097/HJH.0000000000000619
DO - 10.1097/HJH.0000000000000619
M3 - Article
C2 - 26103125
AN - SCOPUS:84942609499
SN - 0263-6352
VL - 33
SP - 1922
EP - 1930
JO - Journal of Hypertension
JF - Journal of Hypertension
IS - 9
ER -