Circadian rhythm-related factors of PER and CRY family genes function as novel therapeutic targets and prognostic biomarkers in lung adenocarcinoma

Chin Chou Wang, Wei Hsun Lin, Su Chi Ku, Wan Jou Shen, Hoang Dang Khoa Ta, Gangga Anuraga, Fang Wen Liu, Chiu Fan Shen, Shu He Wang, Chia Chen Yang, Chih Yang Wang, Wei Jan Wang

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

The period (PER) and cryptochrome (CRY) families play critical roles in circadian rhythms. The imbalance of circadian factors may lead to the occurrence of cancer. Expressions of PER and CRY family members decrease in various cancers. Nevertheless, expression levels, genetic variations, and molecular mechanisms of PER and CRY family members in lung adenocarcinoma (LUAD) and their correlations with prognoses and immune infiltration in LUAD patients are still unclear. In this study, to identify their biological functions in LUAD development, comprehensive high-throughput techniques were applied to analyze the relationships of expressions of PER and CRY family members with genetic variations, molecular mechanisms, and immune infiltration. The present results showed that transcription levels of PER1 and CRY2 in LUAD were significantly downregulated. High expression levels of PER2, PER3, CRY1, and CRY2 indicated longer overall survival. Some cancer signaling pathways were related to PER and CRY family members, such as cell-cycle, histidine metabolism, and progesterone-mediated oocyte maturation pathways. Expressions of PER and CRY family members significantly affected the infiltration of different immune cells. In conclusion, our findings may help better understand the molecular basis of LUAD, and provide new perspectives of PER and CRY family members as novel biomarkers for LUAD.

Original languageEnglish
Pages (from-to)9056-9089
Number of pages34
JournalAging
Volume14
Issue number22
DOIs
Publication statusPublished - 2022

Keywords

  • Biomarker
  • Circadian rhythm
  • Cry
  • Lung adenocarcinoma
  • Per

ASJC Scopus subject areas

  • Ageing
  • Cell Biology

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