Circadian rhythm in the Ca2+-inhibitable adenylyl cyclase activity of the rat striatum

Yijuang Chern; Eminy H.Y. Lee; Hsing Lin Lai; Hai Long Wang; Yi Chao Lee; Yung Hao Ching

doi:10.1016/0014-5793(96)00370-5

Circadian rhythm in the Ca²⁺-inhibitable adenylyl cyclase activity of the rat striatum

Yijuang Chern, Eminy H.Y. Lee, Hsing Lin Lai, Hai Long Wang, Yi Chao Lee, Yung Hao Ching

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

In the present study, we demonstrate that the Ca²⁺-inhibitable adenylyl cyclase (AC) activity in the striatum exhibits a daily oscillation with a peak occurring around 10:00 h. A circadian fluctuation of the AC activity evoked by an A2a adenosine-selective agonist was also observed. Intrastriatal injection of an A2a-selective adenosine agonist or antagonist during the interval in which the Ca²⁺-inhibitable AC activity was at its peak resulted in a more significant alteration of locomotor activity than those observed at a later interval. The marked circadian variation in the Ca²⁺-inhibitable AC activity in the striatum appears to cause a circadian fluctuation in the action of at least one neuromodulator.

Original language	English
Pages (from-to)	205-208
Number of pages	4
Journal	FEBS Letters
Volume	385
Issue number	3
DOIs	https://doi.org/10.1016/0014-5793(96)00370-5
Publication status	Published - May 6 1996
Externally published	Yes

Keywords

Adenosine
Adenylyl cyclase
Circadian rhythm
Locomotor activity
Striatum

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

Access to Document

10.1016/0014-5793(96)00370-5

Cite this

@article{f5f32542bcaa42ce8a02feacff2b322e,

title = "Circadian rhythm in the Ca2+-inhibitable adenylyl cyclase activity of the rat striatum",

abstract = "In the present study, we demonstrate that the Ca2+-inhibitable adenylyl cyclase (AC) activity in the striatum exhibits a daily oscillation with a peak occurring around 10:00 h. A circadian fluctuation of the AC activity evoked by an A2a adenosine-selective agonist was also observed. Intrastriatal injection of an A2a-selective adenosine agonist or antagonist during the interval in which the Ca2+-inhibitable AC activity was at its peak resulted in a more significant alteration of locomotor activity than those observed at a later interval. The marked circadian variation in the Ca2+-inhibitable AC activity in the striatum appears to cause a circadian fluctuation in the action of at least one neuromodulator.",

keywords = "Adenosine, Adenylyl cyclase, Circadian rhythm, Locomotor activity, Striatum",

author = "Yijuang Chern and Lee, {Eminy H.Y.} and Lai, {Hsing Lin} and Wang, {Hai Long} and Lee, {Yi Chao} and Ching, {Yung Hao}",

note = "Funding Information: Acknowledgements: We would like to than Dr. Cyprian Victor Weaver for his helpful suggestions and comments, and Ms. W.-Y. Lee and Mr. K.-T. Lu for their excellent skills in animal surgery and behavior studies. This work was supported by grants from the National Science Council (NSC 84-2331-B-001-029) and Academia Sinica, Taipei, Taiwan, Republic of China.",

year = "1996",

month = may,

day = "6",

doi = "10.1016/0014-5793(96)00370-5",

language = "English",

volume = "385",

pages = "205--208",

journal = "FEBS Letters",

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T1 - Circadian rhythm in the Ca2+-inhibitable adenylyl cyclase activity of the rat striatum

AU - Chern, Yijuang

AU - Lee, Eminy H.Y.

AU - Lai, Hsing Lin

AU - Wang, Hai Long

AU - Lee, Yi Chao

AU - Ching, Yung Hao

N1 - Funding Information: Acknowledgements: We would like to than Dr. Cyprian Victor Weaver for his helpful suggestions and comments, and Ms. W.-Y. Lee and Mr. K.-T. Lu for their excellent skills in animal surgery and behavior studies. This work was supported by grants from the National Science Council (NSC 84-2331-B-001-029) and Academia Sinica, Taipei, Taiwan, Republic of China.

PY - 1996/5/6

Y1 - 1996/5/6

N2 - In the present study, we demonstrate that the Ca2+-inhibitable adenylyl cyclase (AC) activity in the striatum exhibits a daily oscillation with a peak occurring around 10:00 h. A circadian fluctuation of the AC activity evoked by an A2a adenosine-selective agonist was also observed. Intrastriatal injection of an A2a-selective adenosine agonist or antagonist during the interval in which the Ca2+-inhibitable AC activity was at its peak resulted in a more significant alteration of locomotor activity than those observed at a later interval. The marked circadian variation in the Ca2+-inhibitable AC activity in the striatum appears to cause a circadian fluctuation in the action of at least one neuromodulator.

AB - In the present study, we demonstrate that the Ca2+-inhibitable adenylyl cyclase (AC) activity in the striatum exhibits a daily oscillation with a peak occurring around 10:00 h. A circadian fluctuation of the AC activity evoked by an A2a adenosine-selective agonist was also observed. Intrastriatal injection of an A2a-selective adenosine agonist or antagonist during the interval in which the Ca2+-inhibitable AC activity was at its peak resulted in a more significant alteration of locomotor activity than those observed at a later interval. The marked circadian variation in the Ca2+-inhibitable AC activity in the striatum appears to cause a circadian fluctuation in the action of at least one neuromodulator.

KW - Adenosine

KW - Adenylyl cyclase

KW - Circadian rhythm

KW - Locomotor activity

KW - Striatum

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