Cigarette smoking stimulates lipoxygenase but not cyclooxygenase pathway in platelets

Wen Chang Chang; Shoshi Fukuda; Hsin Hsiung Tai

doi:10.1016/S0006-291X(83)80172-7

Cigarette smoking stimulates lipoxygenase but not cyclooxygenase pathway in platelets

Wen Chang Chang, Shoshi Fukuda, Hsin Hsiung Tai

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Male rats were exposed to freshly generated cigarette smoke once daily for 4 to 8 weeks. Inhalation of smoke was verified by elevated level of carboxyhemoglobin. Arachidonate metabolism through lipoxygenase and cyclooxygenase pathways in platelets was determined. Cigarette smoking increased 12-lipoxygenase activity significantly without affecting the cyclooxygenase pathway. In view of platelet-leukocyte interactions and potent chemotactic activity of 12-HETE for aortic smooth muscle cell migration, increased 12-lipoxygenase activity may predispose individuals to atherosclerosis, thromboembolism and emphysema commonly found in smokers.

Original language	English
Pages (from-to)	499-505
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	115
Issue number	2
DOIs	https://doi.org/10.1016/S0006-291X(83)80172-7
Publication status	Published - Sept 15 1983
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/S0006-291X(83)80172-7

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title = "Cigarette smoking stimulates lipoxygenase but not cyclooxygenase pathway in platelets",

abstract = "Male rats were exposed to freshly generated cigarette smoke once daily for 4 to 8 weeks. Inhalation of smoke was verified by elevated level of carboxyhemoglobin. Arachidonate metabolism through lipoxygenase and cyclooxygenase pathways in platelets was determined. Cigarette smoking increased 12-lipoxygenase activity significantly without affecting the cyclooxygenase pathway. In view of platelet-leukocyte interactions and potent chemotactic activity of 12-HETE for aortic smooth muscle cell migration, increased 12-lipoxygenase activity may predispose individuals to atherosclerosis, thromboembolism and emphysema commonly found in smokers.",

author = "Chang, {Wen Chang} and Shoshi Fukuda and Tai, {Hsin Hsiung}",

note = "Funding Information: We are greatly indebted to Ms. Sharon Parker for her excellent technical assistance and to Ms. Laurie Benton for her preparation of the manuscript. We are also grateful to Mr. Phil Wiseman for smoke inhalation. This study was supported in part by KTRB grant 4B506 from the Kentucky Tobacco Research Board.",

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T1 - Cigarette smoking stimulates lipoxygenase but not cyclooxygenase pathway in platelets

AU - Chang, Wen Chang

AU - Fukuda, Shoshi

AU - Tai, Hsin Hsiung

N1 - Funding Information: We are greatly indebted to Ms. Sharon Parker for her excellent technical assistance and to Ms. Laurie Benton for her preparation of the manuscript. We are also grateful to Mr. Phil Wiseman for smoke inhalation. This study was supported in part by KTRB grant 4B506 from the Kentucky Tobacco Research Board.

PY - 1983/9/15

Y1 - 1983/9/15

N2 - Male rats were exposed to freshly generated cigarette smoke once daily for 4 to 8 weeks. Inhalation of smoke was verified by elevated level of carboxyhemoglobin. Arachidonate metabolism through lipoxygenase and cyclooxygenase pathways in platelets was determined. Cigarette smoking increased 12-lipoxygenase activity significantly without affecting the cyclooxygenase pathway. In view of platelet-leukocyte interactions and potent chemotactic activity of 12-HETE for aortic smooth muscle cell migration, increased 12-lipoxygenase activity may predispose individuals to atherosclerosis, thromboembolism and emphysema commonly found in smokers.

AB - Male rats were exposed to freshly generated cigarette smoke once daily for 4 to 8 weeks. Inhalation of smoke was verified by elevated level of carboxyhemoglobin. Arachidonate metabolism through lipoxygenase and cyclooxygenase pathways in platelets was determined. Cigarette smoking increased 12-lipoxygenase activity significantly without affecting the cyclooxygenase pathway. In view of platelet-leukocyte interactions and potent chemotactic activity of 12-HETE for aortic smooth muscle cell migration, increased 12-lipoxygenase activity may predispose individuals to atherosclerosis, thromboembolism and emphysema commonly found in smokers.

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Cigarette smoking stimulates lipoxygenase but not cyclooxygenase pathway in platelets

Abstract

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