Rationale: The association between chronic obstructive pulmonary disease (COPD) and functional gastrointestinal disorders (FGIDs) remains unclear. Methods: Using Taiwan's National Health Insurance Research Database, we conducted a nationwide population-based study to explore the relationship of COPD and future FGIDs development. The COPD cohort consisted of 4107 patients with COPD between 2000 and 2005. For a comparison cohort, 12,321 age- and gender-matched patients without COPD were randomly selected. The two cohorts were tracked for 5 year and observed for occurrence of FGIDs. The operational definition of COPD in the Korean Health Insurance Review and Assessment Service database was used to validate the results. The validation study confirmed the accuracy of definitions of COPD (83.5% sensitivity). Results: The adjusted hazard ratios (aHR) of FGIDs in patients with COPD was higher (aHR: 1.63; 95% confidence interval (CI): 1.45–1.83; P <.001) than that of the comparison patients. In our secondary analysis in which FGIDs was divided into gastroesophageal reflux disease, irritable bowel syndrome and functional dyspepsia. Patients with COPD also had higher risk for all three subtypes of FGIDs: irritable bowel syndrome (aHR: 1.55; 95% confidence interval (CI): 1.27–1.90; P <.001), gastroesophageal reflux disease (aHR: 2.10; 95% confidence interval (CI): 1.76–2.49; P <.001), and functional dyspepsia (aHR: 1.34; 95% confidence interval (CI): 1.11–1.62; P =.003). The results in validated COPD group were consistent with those in unvalidated COPD group. Conclusion: Patients with COPD appeared to be at higher risk for future FGIDs.

Original languageEnglish
Article number106833
JournalRespiratory Medicine
Publication statusPublished - Jun 2022


  • COPD
  • Functional gastrointestinal disorders
  • Gastroesophageal reflux disease
  • Irritable bowel syndrome and functional dyspepsia

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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