Chronic hepatitis B virus infection associated with increased colorectal cancer risk in Taiwanese population

Fu Hsiung Su, Thi Nga Le, Chih Hsin Muo, Sister Arlene Te, Fung Chang Sung, Chih Ching Yeh

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


Chronic hepatitis B virus (HBV) infections and colorectal cancer (CRC) are prevalent in Taiwan. We carried out a population-based case-control study to assess the association between HBV infection and CRC risk. Using the National Health Insurance Research Database of Taiwan, we identified 69,478 newly diagnosed patients with CRC from 2005 to 2011. We further randomly selected 69,478 age- and gender-matched controls without CRC from the same database. Odds ratios (ORs) were calculated to evaluate the association between chronic HBV infection and CRC using a logistic regression analysis. HBV infection was found to be associated with the risk of CRC (OR = 1.27, 95% confidence interval (CI) = 1.20–1.33). This relationship was similar in men and women. Age-specific analysis revealed that the CRC risk associated with HBV decreased with age. The adjusted ORs for patients aged <55, 55–64, and 65–74 years were 1.63 (95% CI = 1.48–1.79), 1.24 (95% CI = 1.13–1.37), and 1.02 (95% = 0.92–1.13), respectively. In conclusion, this study suggests that chronic HBV infection is significantly associated with an increased risk of CRC. Monitoring the risk of CRC development in young patients with HBV infection is crucial.

Original languageEnglish
Article number97
Issue number1
Publication statusPublished - Jan 1 2020


  • Case-control study
  • Colorectal cancer
  • Hepatitis B virus
  • Population-based

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology


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