Chronic granulocytic leukemia (CGL) during the course of chronic lymphocytic leukemia (CLL): correlation of blood, marrow, and spleen morphology and cytogenetics

J. Whang-Peng; H. R. Gralnick; R. E. Johnson; E. C. Lee; A. Lear

Chronic granulocytic leukemia (CGL) during the course of chronic lymphocytic leukemia (CLL): correlation of blood, marrow, and spleen morphology and cytogenetics

J. Whang-Peng, H. R. Gralnick, R. E. Johnson, E. C. Lee, A. Lear

Research output: Contribution to journal › Article › peer-review

Abstract

Secondary malignant conditions occur with a greater frequency in patients with chronic lymphatic leukemia (CLL) than in the general population. Previously, 20 patients with CLL were reported as developing acute leukemia, but no cases of the development of chronic granulocytic leukemia (CGL) were observed. The authors describe patients with Ph ¹ chromosome positive CGL associated with previously described CLL. One patient received total body radiation treatment for his CLL, while the second was not treated. It is apparent that previous therapy may not necessarily be a prerequisite for the development of a second malignancy in CLL. Cytogenetics offers a useful tool to confirm morphologic criteria in establishing the diagnosis of a second neoplasm.

Original language	English
Pages (from-to)	333-339
Number of pages	7
Journal	Blood
Volume	43
Issue number	3
Publication status	Published - Dec 1 1974
Externally published	Yes

ASJC Scopus subject areas

Hematology

Cite this

@article{d2bc7c471bbb4676a63d365d87bdee50,

title = "Chronic granulocytic leukemia (CGL) during the course of chronic lymphocytic leukemia (CLL): correlation of blood, marrow, and spleen morphology and cytogenetics",

abstract = "Secondary malignant conditions occur with a greater frequency in patients with chronic lymphatic leukemia (CLL) than in the general population. Previously, 20 patients with CLL were reported as developing acute leukemia, but no cases of the development of chronic granulocytic leukemia (CGL) were observed. The authors describe patients with Ph 1 chromosome positive CGL associated with previously described CLL. One patient received total body radiation treatment for his CLL, while the second was not treated. It is apparent that previous therapy may not necessarily be a prerequisite for the development of a second malignancy in CLL. Cytogenetics offers a useful tool to confirm morphologic criteria in establishing the diagnosis of a second neoplasm.",

author = "J. Whang-Peng and Gralnick, {H. R.} and Johnson, {R. E.} and Lee, {E. C.} and A. Lear",

year = "1974",

month = dec,

day = "1",

language = "English",

volume = "43",

pages = "333--339",

journal = "Blood",

issn = "0006-4971",

publisher = "American Society of Hematology",

number = "3",

}

TY - JOUR

T1 - Chronic granulocytic leukemia (CGL) during the course of chronic lymphocytic leukemia (CLL)

T2 - correlation of blood, marrow, and spleen morphology and cytogenetics

AU - Whang-Peng, J.

AU - Gralnick, H. R.

AU - Johnson, R. E.

AU - Lee, E. C.

AU - Lear, A.

PY - 1974/12/1

Y1 - 1974/12/1

N2 - Secondary malignant conditions occur with a greater frequency in patients with chronic lymphatic leukemia (CLL) than in the general population. Previously, 20 patients with CLL were reported as developing acute leukemia, but no cases of the development of chronic granulocytic leukemia (CGL) were observed. The authors describe patients with Ph 1 chromosome positive CGL associated with previously described CLL. One patient received total body radiation treatment for his CLL, while the second was not treated. It is apparent that previous therapy may not necessarily be a prerequisite for the development of a second malignancy in CLL. Cytogenetics offers a useful tool to confirm morphologic criteria in establishing the diagnosis of a second neoplasm.

AB - Secondary malignant conditions occur with a greater frequency in patients with chronic lymphatic leukemia (CLL) than in the general population. Previously, 20 patients with CLL were reported as developing acute leukemia, but no cases of the development of chronic granulocytic leukemia (CGL) were observed. The authors describe patients with Ph 1 chromosome positive CGL associated with previously described CLL. One patient received total body radiation treatment for his CLL, while the second was not treated. It is apparent that previous therapy may not necessarily be a prerequisite for the development of a second malignancy in CLL. Cytogenetics offers a useful tool to confirm morphologic criteria in establishing the diagnosis of a second neoplasm.

UR - http://www.scopus.com/inward/record.url?scp=0016366864&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016366864&partnerID=8YFLogxK

M3 - Article

C2 - 4521368

AN - SCOPUS:0016366864

SN - 0006-4971

VL - 43

SP - 333

EP - 339

JO - Blood

JF - Blood

IS - 3

ER -

Chronic granulocytic leukemia (CGL) during the course of chronic lymphocytic leukemia (CLL): correlation of blood, marrow, and spleen morphology and cytogenetics

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this