Chromosome positional effects of gene expressions after cellular senescence

Hung Lin Chen; Ching You Lu; Yi Hsin Hsu; Jing Jer Lin

doi:10.1016/j.bbrc.2003.11.146

Chromosome positional effects of gene expressions after cellular senescence

Hung Lin Chen
, Ching You Lu
, Yi Hsin Hsu
, Jing Jer Lin

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Normal human fibroblasts stop dividing after a limited number of cell divisions termed cellular senescence. Telomere shortening has been shown to be the main factor that causes cellular senescence, however, the molecular mechanism of how telomere shortening causes cellular senescence is unclear. Here we analyze the relationship between gene expressions and their chromosomal locations during cellular senescence. It appears that the expression of genes located in chromosome 4 is preferentially altered after senescence. Moreover, we identify four chromosomal loci in which gene expressions are affected by senescence. Finally, we show that there is no preferential alteration of telomere-proximal genes during cellular senescence, implying that cellular senescence is not caused by derepression of telomere-proximal genes.

Original language	English
Pages (from-to)	576-586
Number of pages	11
Journal	Biochemical and Biophysical Research Communications
Volume	313
Issue number	3
DOIs	https://doi.org/10.1016/j.bbrc.2003.11.146
Publication status	Published - Jan 16 2004
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/j.bbrc.2003.11.146

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title = "Chromosome positional effects of gene expressions after cellular senescence",

abstract = "Normal human fibroblasts stop dividing after a limited number of cell divisions termed cellular senescence. Telomere shortening has been shown to be the main factor that causes cellular senescence, however, the molecular mechanism of how telomere shortening causes cellular senescence is unclear. Here we analyze the relationship between gene expressions and their chromosomal locations during cellular senescence. It appears that the expression of genes located in chromosome 4 is preferentially altered after senescence. Moreover, we identify four chromosomal loci in which gene expressions are affected by senescence. Finally, we show that there is no preferential alteration of telomere-proximal genes during cellular senescence, implying that cellular senescence is not caused by derepression of telomere-proximal genes.",

author = "Chen, \{Hung Lin\} and Lu, \{Ching You\} and Hsu, \{Yi Hsin\} and Lin, \{Jing Jer\}",

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AU - Chen, Hung Lin

AU - Lu, Ching You

AU - Hsu, Yi Hsin

AU - Lin, Jing Jer

PY - 2004/1/16

Y1 - 2004/1/16

N2 - Normal human fibroblasts stop dividing after a limited number of cell divisions termed cellular senescence. Telomere shortening has been shown to be the main factor that causes cellular senescence, however, the molecular mechanism of how telomere shortening causes cellular senescence is unclear. Here we analyze the relationship between gene expressions and their chromosomal locations during cellular senescence. It appears that the expression of genes located in chromosome 4 is preferentially altered after senescence. Moreover, we identify four chromosomal loci in which gene expressions are affected by senescence. Finally, we show that there is no preferential alteration of telomere-proximal genes during cellular senescence, implying that cellular senescence is not caused by derepression of telomere-proximal genes.

AB - Normal human fibroblasts stop dividing after a limited number of cell divisions termed cellular senescence. Telomere shortening has been shown to be the main factor that causes cellular senescence, however, the molecular mechanism of how telomere shortening causes cellular senescence is unclear. Here we analyze the relationship between gene expressions and their chromosomal locations during cellular senescence. It appears that the expression of genes located in chromosome 4 is preferentially altered after senescence. Moreover, we identify four chromosomal loci in which gene expressions are affected by senescence. Finally, we show that there is no preferential alteration of telomere-proximal genes during cellular senescence, implying that cellular senescence is not caused by derepression of telomere-proximal genes.

UR - https://www.scopus.com/pages/publications/0347694726

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DO - 10.1016/j.bbrc.2003.11.146

M3 - Article

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AN - SCOPUS:0347694726

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SP - 576

EP - 586

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 3

ER -

Chromosome positional effects of gene expressions after cellular senescence

Abstract

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