Chondroprotective effects of genistein against osteoarthritis induced joint inflammation

Feng Cheng Liu, Chih Chien Wang, Jeng Wei Lu, Chian Her Lee, Shao Chi Chen, Yi Jung Ho, Yi Jen Peng

Research output: Contribution to journalArticlepeer-review

52 Citations (Scopus)


Genistein is an isoflavone extracted from soybean (Glycine max). This compound has anti-inflammatory, anti-oxidative, and anti-cancer effects; however, the mechanism underlying the effects of genistein on IL-1β-stimulated human osteoarthritis (OA) chondrocytes remains unknown. Our objectives in this study were to explore the anti-inflammatory effects of genistein on IL-1β-stimulated human OA chondrocytes and to investigate the potential mechanisms which underlie them. Our results from an in-vitro model of osteoarthritis indicate that genistein inhibits the IL-1β-induced expression of the catabolic factors nitric oxide synthase 2 (NOS2), cyclooxygenase 2 (COX-2), and matrix metalloproteinases (MMPs). Genistein was shown to stimulate Ho-1 expression, which has been associated with Nrf-2 pathway activation in human chondrocytes. In a rat model, genistein was also shown to attenuate the progression of traumatic osteoarthritis. Taken together, these results demonstrate the effectiveness of genistein in mediating the inflammation associated with joint disorders. Our results also indicate that genistein could potentially serve as an alternative therapeutic treatment for OA.

Original languageEnglish
Article number1180
Issue number5
Publication statusPublished - May 2019


  • Genistein
  • IL-1β
  • Inflammation
  • Osteoarthritis

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics


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