Cholesteric liquid crystal biosensor platform with image analysis for rapid detection of COVID-19

Ping Yuan Lin; Yi Wei Chung; Er Yuan Chuang; Yen Chieh Wang; Min Chih Lai; Yen Chin Hsu; Chun Che Lin; Yu Cheng Hsiao

doi:10.3389/fbioe.2023.1148446

Cholesteric liquid crystal biosensor platform with image analysis for rapid detection of COVID-19

Ping Yuan Lin, Yi Wei Chung, Er Yuan Chuang, Yen Chieh Wang, Min Chih Lai, Yen Chin Hsu, Chun Che Lin, Yu Cheng Hsiao

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Rapid and low-cost diagnosis of coronavirus disease 2019 (COVID-19) is essential to identify infected subjects, particularly asymptomatic cases, primarily to arrest the spread of the disease through local transmission. Antibody-based chromatographic serological tests, as an alternative to the RT-PCR technique, offer only limited help due to high false positives. We propose to exploit our cholesteric liquid crystal biosensor platform for one-step, wash-free, rapid detection of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus directly with minimal sample pre-processing. As mentioned above, cholesteric liquid crystals are an effective and innovative approach to healthcare as a rapid test for the diagnosis of COVID-19 and other diseases.

Original language	English
Article number	1148446
Journal	Frontiers in Bioengineering and Biotechnology
Volume	11
DOIs	https://doi.org/10.3389/fbioe.2023.1148446
Publication status	Published - 2023

Keywords

biosensor
cholesteric liquid crystal
COVID-19
diagnosis
spike protein

ASJC Scopus subject areas

Biotechnology
Bioengineering
Histology
Biomedical Engineering

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10.3389/fbioe.2023.1148446

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title = "Cholesteric liquid crystal biosensor platform with image analysis for rapid detection of COVID-19",

abstract = "Rapid and low-cost diagnosis of coronavirus disease 2019 (COVID-19) is essential to identify infected subjects, particularly asymptomatic cases, primarily to arrest the spread of the disease through local transmission. Antibody-based chromatographic serological tests, as an alternative to the RT-PCR technique, offer only limited help due to high false positives. We propose to exploit our cholesteric liquid crystal biosensor platform for one-step, wash-free, rapid detection of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus directly with minimal sample pre-processing. As mentioned above, cholesteric liquid crystals are an effective and innovative approach to healthcare as a rapid test for the diagnosis of COVID-19 and other diseases.",

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author = "Lin, {Ping Yuan} and Chung, {Yi Wei} and Chuang, {Er Yuan} and Wang, {Yen Chieh} and Lai, {Min Chih} and Hsu, {Yen Chin} and Lin, {Chun Che} and Hsiao, {Yu Cheng}",

note = "Funding Information: This research work was financially supported by grants from Taipei Medical University Hospital (109TMU-TMUH-02), Shuangho Hospital, Ministry of Health And Welfare (111FRP-06) and the Ministry of Science and Technology (MOST), Taiwan (MOST 108-2221-E-038-017-MY3, 109-2636-E-038-001, 111-2320-B-038-039, and 108-2320-B-038-061-MY3), University System of Taipei under grant number. USTP-NTUT-TMU-109-02. Publisher Copyright: Copyright {\textcopyright} 2023 Lin, Chung, Chuang, Wang, Lai, Hsu, Lin and Hsiao.",

year = "2023",

doi = "10.3389/fbioe.2023.1148446",

language = "English",

volume = "11",

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AU - Lin, Ping Yuan

AU - Chung, Yi Wei

AU - Chuang, Er Yuan

AU - Wang, Yen Chieh

AU - Lai, Min Chih

AU - Hsu, Yen Chin

AU - Lin, Chun Che

AU - Hsiao, Yu Cheng

N1 - Funding Information: This research work was financially supported by grants from Taipei Medical University Hospital (109TMU-TMUH-02), Shuangho Hospital, Ministry of Health And Welfare (111FRP-06) and the Ministry of Science and Technology (MOST), Taiwan (MOST 108-2221-E-038-017-MY3, 109-2636-E-038-001, 111-2320-B-038-039, and 108-2320-B-038-061-MY3), University System of Taipei under grant number. USTP-NTUT-TMU-109-02. Publisher Copyright: Copyright © 2023 Lin, Chung, Chuang, Wang, Lai, Hsu, Lin and Hsiao.

PY - 2023

Y1 - 2023

N2 - Rapid and low-cost diagnosis of coronavirus disease 2019 (COVID-19) is essential to identify infected subjects, particularly asymptomatic cases, primarily to arrest the spread of the disease through local transmission. Antibody-based chromatographic serological tests, as an alternative to the RT-PCR technique, offer only limited help due to high false positives. We propose to exploit our cholesteric liquid crystal biosensor platform for one-step, wash-free, rapid detection of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus directly with minimal sample pre-processing. As mentioned above, cholesteric liquid crystals are an effective and innovative approach to healthcare as a rapid test for the diagnosis of COVID-19 and other diseases.

AB - Rapid and low-cost diagnosis of coronavirus disease 2019 (COVID-19) is essential to identify infected subjects, particularly asymptomatic cases, primarily to arrest the spread of the disease through local transmission. Antibody-based chromatographic serological tests, as an alternative to the RT-PCR technique, offer only limited help due to high false positives. We propose to exploit our cholesteric liquid crystal biosensor platform for one-step, wash-free, rapid detection of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus directly with minimal sample pre-processing. As mentioned above, cholesteric liquid crystals are an effective and innovative approach to healthcare as a rapid test for the diagnosis of COVID-19 and other diseases.

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KW - spike protein

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Cholesteric liquid crystal biosensor platform with image analysis for rapid detection of COVID-19

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Keywords

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