Chemistry and biochemistry of the streptovaricins. XII. Atropisomeric streptovaricins

Kenneth L. Rinehart; Waltraut M.J. Knoll; Katsumi Kakinuma; Frederick J. Antosz; Iain C. Paul; Andrew H.J. Wang; Fritz Reusser; L. H. Li; William C. Krueger

doi:10.1021/ja00834a039

Chemistry and biochemistry of the streptovaricins. XII. Atropisomeric streptovaricins

Kenneth L. Rinehart, Waltraut M.J. Knoll, Katsumi Kakinuma, Frederick J. Antosz, Iain C. Paul, Andrew H.J. Wang, Fritz Reusser, L. H. Li, William C. Krueger

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

The streptovaricins (and other ansamycin antibiotics)³ derive an intrinsic helicity from their ansa rings. In connection with extensive studies of the biological activities of the streptovaricins and their derivatives, 2 we have examined the effect of this helicity on the activities displayed.

Original language	English
Pages (from-to)	196-198
Number of pages	3
Journal	Journal of the American Chemical Society
Volume	97
Issue number	1
DOIs	https://doi.org/10.1021/ja00834a039
Publication status	Published - Jan 1 1975
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja00834a039

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abstract = "The streptovaricins (and other ansamycin antibiotics)3 derive an intrinsic helicity from their ansa rings. In connection with extensive studies of the biological activities of the streptovaricins and their derivatives, 2 we have examined the effect of this helicity on the activities displayed.",

author = "Rinehart, {Kenneth L.} and Knoll, {Waltraut M.J.} and Katsumi Kakinuma and Antosz, {Frederick J.} and Paul, {Iain C.} and Wang, {Andrew H.J.} and Fritz Reusser and Li, {L. H.} and Krueger, {William C.}",

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AU - Rinehart, Kenneth L.

AU - Knoll, Waltraut M.J.

AU - Kakinuma, Katsumi

AU - Antosz, Frederick J.

AU - Paul, Iain C.

AU - Wang, Andrew H.J.

AU - Reusser, Fritz

AU - Li, L. H.

AU - Krueger, William C.

PY - 1975/1/1

Y1 - 1975/1/1

N2 - The streptovaricins (and other ansamycin antibiotics)3 derive an intrinsic helicity from their ansa rings. In connection with extensive studies of the biological activities of the streptovaricins and their derivatives, 2 we have examined the effect of this helicity on the activities displayed.

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Chemistry and biochemistry of the streptovaricins. XII. Atropisomeric streptovaricins

Abstract

ASJC Scopus subject areas

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